Difference between revisions of "MntC"

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(Expression and regulation)
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=Expression and regulation=
 
=Expression and regulation=
 
 
* '''Operon:''' ''[[mntA]]-[[mntB]]-[[mntC]]-[[mntD]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/10760146 PubMed]
 
* '''Operon:''' ''[[mntA]]-[[mntB]]-[[mntC]]-[[mntD]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/10760146 PubMed]
  
 
* '''[[Sigma factor]]:'''  
 
* '''[[Sigma factor]]:'''  
  
* '''Regulation:''' repressed by Mn(2+) ([[MntR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/10760146 PubMed]
+
* '''Regulation:'''  
** activated at low Mn(II) concentrations (MntR) [http://www.ncbi.nlm.nih.gov/sites/entrez/10760146 PubMed]
+
** activated at low Mn(II) concentrations ([[MntR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/10760146 PubMed]
  
* '''Regulatory mechanism:''' MntR: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/10760146 PubMed]
+
* '''Regulatory mechanism:'''  
 
** [[MntR]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/10760146 PubMed]
 
** [[MntR]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/10760146 PubMed]
  
* '''Additional information:'''  
+
* '''Additional information:'''
  
 
=Biological materials =
 
=Biological materials =

Revision as of 20:44, 19 December 2009

  • Description: manganese ABC transporter (membrane protein)

Gene name mntC
Synonyms ytgC
Essential no
Product manganese ABC transporter (membrane protein)))
Function manganese uptake
Metabolic function and regulation of this protein in SubtiPathways:
Stress
MW, pI 47 kDa, 9.354
Gene length, protein length 1305 bp, 435 aa
Immediate neighbours mntD, mntB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
MntC context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU30750

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: ABC-3 integral membrane protein family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cell membrane (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • activated at low Mn(II) concentrations (MntR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage

Your additional remarks

References

Emmanuel Guedon, Charles M Moore, Qiang Que, Tao Wang, Rick W Ye, John D Helmann
The global transcriptional response of Bacillus subtilis to manganese involves the MntR, Fur, TnrA and sigmaB regulons.
Mol Microbiol: 2003, 49(6);1477-91
[PubMed:12950915] [WorldCat.org] [DOI] (P p)

Q Que, J D Helmann
Manganese homeostasis in Bacillus subtilis is regulated by MntR, a bifunctional regulator related to the diphtheria toxin repressor family of proteins.
Mol Microbiol: 2000, 35(6);1454-68
[PubMed:10760146] [WorldCat.org] [DOI] (P p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)