Difference between revisions of "YhdN"

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* '''Description:''' general stress protein, aldo/keto reductase <br/><br/>
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* '''Description:''' general stress protein, broad specificity aldo-keto reductase that converts MG to acetol <br/><br/>
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
 
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|style="background:#ABCDEF;" align="center"| '''Product''' || aldo/keto reductase, specific for NADP  
 
|style="background:#ABCDEF;" align="center"| '''Product''' || aldo/keto reductase, specific for NADP  
 
|-
 
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || unknown
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|style="background:#ABCDEF;" align="center"|'''Function''' || detoxification of methylglyoxal
 
|-
 
|-
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU09530 yhdN]
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU09530 yhdN]
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= [[Categories]] containing this gene/protein =
 
= [[Categories]] containing this gene/protein =
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=== Additional information===
 
=== Additional information===
 
 
 
  
 
=The protein=
 
=The protein=
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* '''Kinetic information:'''
 
* '''Kinetic information:'''
  
* '''Domains:'''  
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* '''[[Domains]]:'''  
  
 
* '''Modification:'''
 
* '''Modification:'''
  
* '''Cofactor(s):'''
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* '''[[Cofactors]]:'''
  
 
* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yhdN_1030265_1031260_1 yhdN] {{PubMed|22383849}}
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yhdN_1030265_1031260_1 yhdN] {{PubMed|22383849}}
  
* '''Sigma factor:''' [[SigB]] {{PubMed|10220166,15805528}}  
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* '''[[Sigma factor]]:''' [[SigB]] {{PubMed|10220166,15805528}}  
  
 
* '''Regulation:'''   
 
* '''Regulation:'''   
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=References=
 
=References=
  
<pubmed>10220166,15019785,,12737802,15805528, </pubmed>
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<pubmed>10220166,15019785, 24330391,12737802,15805528, </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 18:12, 7 January 2014

  • Description: general stress protein, broad specificity aldo-keto reductase that converts MG to acetol

Gene name yhdN
Synonyms
Essential no
Product aldo/keto reductase, specific for NADP
Function detoxification of methylglyoxal
Gene expression levels in SubtiExpress: yhdN
Metabolic function and regulation of this protein in SubtiPathways:
yhdN
MW, pI 37 kDa, 4.77
Gene length, protein length 993 bp, 331 aa
Immediate neighbours sigM, plsC
Sequences Protein DNA DNA_with_flanks
Genetic context
YhdN context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YhdN expression.png















Categories containing this gene/protein

biosynthesis of lipids, general stress proteins (controlled by SigB)

This gene is a member of the following regulons

SigB regulon

The gene

Basic information

  • Locus tag: BSU09530

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: aldo/keto reductase 2 family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Pete Chandrangsu, Renata Dusi, Chris J Hamilton, John D Helmann
Methylglyoxal resistance in Bacillus subtilis: contributions of bacillithiol-dependent and independent pathways.
Mol Microbiol: 2014, 91(4);706-15
[PubMed:24330391] [WorldCat.org] [DOI] (I p)

Dirk Höper, Uwe Völker, Michael Hecker
Comprehensive characterization of the contribution of individual SigB-dependent general stress genes to stress resistance of Bacillus subtilis.
J Bacteriol: 2005, 187(8);2810-26
[PubMed:15805528] [WorldCat.org] [DOI] (P p)

Andreas H Ehrensberger, David K Wilson
Structural and catalytic diversity in the two family 11 aldo-keto reductases.
J Mol Biol: 2004, 337(3);661-73
[PubMed:15019785] [WorldCat.org] [DOI] (P p)

Gustavo E Schujman, Luciana Paoletti, Alan D Grossman, Diego de Mendoza
FapR, a bacterial transcription factor involved in global regulation of membrane lipid biosynthesis.
Dev Cell: 2003, 4(5);663-72
[PubMed:12737802] [WorldCat.org] [DOI] (P p)

Anja Petersohn, Haike Antelmann, Ulf Gerth, Michael Hecker
Identification and transcriptional analysis of new members of the sigmaB regulon in Bacillus subtilis.
Microbiology (Reading): 1999, 145 ( Pt 4);869-880
[PubMed:10220166] [WorldCat.org] [DOI] (P p)