Difference between revisions of "TagO"
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| − | * '''Description:''' teichoic acid linkage unit synthesis <br/><br/> | + | * '''Description:''' undecaprenyl-phosphate-GlcNAc-1-phosphate transferase, teichoic acid linkage unit synthesis <br/><br/> |
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|style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed] | |style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed] | ||
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| − | |style="background:#ABCDEF;" align="center"| '''Product''' || | + | |style="background:#ABCDEF;" align="center"| '''Product''' || undecaprenyl-phosphate-GlcNAc-1-phosphate transferase |
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|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of teichoic acid | |style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of teichoic acid | ||
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=== Additional information=== | === Additional information=== | ||
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=tagO_3648654_3649730_-1 tagO] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=tagO_3648654_3649730_-1 tagO] {{PubMed|22383849}} | ||
| − | * '''Sigma factor:''' | + | * '''[[Sigma factor]]:''' |
* '''Regulation:''' | * '''Regulation:''' | ||
Revision as of 10:34, 30 August 2013
- Description: undecaprenyl-phosphate-GlcNAc-1-phosphate transferase, teichoic acid linkage unit synthesis
| Gene name | tagO |
| Synonyms | yvhI |
| Essential | yes PubMed |
| Product | undecaprenyl-phosphate-GlcNAc-1-phosphate transferase |
| Function | biosynthesis of teichoic acid |
| Gene expression levels in SubtiExpress: tagO | |
| MW, pI | 39 kDa, 10.424 |
| Gene length, protein length | 1074 bp, 358 aa |
| Immediate neighbours | tagV, tuaH |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
cell wall synthesis, biosynthesis of cell wall components, essential genes, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU35530
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: UDP-N-acetyl-D-glucosamine + undecaprenyl phosphate = UMP + N-acetyl-alpha-D-glucosaminyldiphospho-undecaprenol (according to Swiss-Prot)
- Protein family: glycosyltransferase 4 family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: O34753
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Yoshimasa Ishizaki, Chigusa Hayashi, Kunio Inoue, Masayuki Igarashi, Yoshiaki Takahashi, Venugopal Pujari, Dean C Crick, Patrick J Brennan, Akio Nomoto
Inhibition of the first step in synthesis of the mycobacterial cell wall core, catalyzed by the GlcNAc-1-phosphate transferase WecA, by the novel caprazamycin derivative CPZEN-45.
J Biol Chem: 2013, 288(42);30309-30319
[PubMed:23986448]
[WorldCat.org]
[DOI]
(I p)
Alex Formstone, Rut Carballido-López, Philippe Noirot, Jeffery Errington, Dirk-Jan Scheffers
Localization and interactions of teichoic acid synthetic enzymes in Bacillus subtilis.
J Bacteriol: 2008, 190(5);1812-21
[PubMed:18156271]
[WorldCat.org]
[DOI]
(I p)
Blazenka Soldo, Vladimir Lazarevic, Dimitri Karamata
tagO is involved in the synthesis of all anionic cell-wall polymers in Bacillus subtilis 168.
Microbiology (Reading): 2002, 148(Pt 7);2079-2087
[PubMed:12101296]
[WorldCat.org]
[DOI]
(P p)
