Difference between revisions of "ComER"

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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[comEA]]'', ''[[yqeM]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[comEA]]'', ''[[yqeM]]''
 
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU25600 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU25600 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU25600 Advanced_DNA]
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU25600 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU25600 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU25600 DNA_with_flanks]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:comER_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:comER_context.gif]]

Revision as of 10:46, 14 May 2013

  • Description: non-essential gene for competence

Gene name comER
Synonyms comD, comED
Essential no
Product putative pyrroline-5'-carboxylate reductase
Function genetic compentence
Gene expression levels in SubtiExpress: comER
MW, pI 30 kDa, 6.183
Gene length, protein length 819 bp, 273 aa
Immediate neighbours comEA, yqeM
Sequences Protein DNA DNA_with_flanks
Genetic context
ComER context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
ComER expression.png
























Categories containing this gene/protein

genetic competence, membrane proteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU25600

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: pyrroline-5-carboxylate reductase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation: repressed by casamino acids PubMed
  • Regulatory mechanism:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Irnov Irnov, Cynthia M Sharma, Jörg Vogel, Wade C Winkler
Identification of regulatory RNAs in Bacillus subtilis.
Nucleic Acids Res: 2010, 38(19);6637-51
[PubMed:20525796] [WorldCat.org] [DOI] (I p)

Ulrike Mäder, Georg Homuth, Christian Scharf, Knut Büttner, Rüdiger Bode, Michael Hecker
Transcriptome and proteome analysis of Bacillus subtilis gene expression modulated by amino acid availability.
J Bacteriol: 2002, 184(15);4288-95
[PubMed:12107147] [WorldCat.org] [DOI] (P p)

Hanne Jarmer, Randy Berka, Steen Knudsen, Hans H Saxild
Transcriptome analysis documents induced competence of Bacillus subtilis during nitrogen limiting conditions.
FEMS Microbiol Lett: 2002, 206(2);197-200
[PubMed:11814663] [WorldCat.org] [DOI] (P p)

B R Belitsky, J Brill, E Bremer, A L Sonenshein
Multiple genes for the last step of proline biosynthesis in Bacillus subtilis.
J Bacteriol: 2001, 183(14);4389-92
[PubMed:11418582] [WorldCat.org] [DOI] (P p)

J Hahn, G Inamine, Y Kozlov, D Dubnau
Characterization of comE, a late competence operon of Bacillus subtilis required for the binding and uptake of transforming DNA.
Mol Microbiol: 1993, 10(1);99-111
[PubMed:7968523] [WorldCat.org] [DOI] (P p)