Difference between revisions of "GbsB"

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|style="background:#ABCDEF;" align="center"|'''Function''' || osmoprotection
 
|style="background:#ABCDEF;" align="center"|'''Function''' || osmoprotection
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU31050 gbsB]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU31050 gbsB]
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]'''
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]'''
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yuaD]]'', ''[[gbsA]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yuaD]]'', ''[[gbsA]]''
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB15083&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU31050 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU31050 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU31050 Advanced_DNA]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:gbsB_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:gbsB_context.gif]]

Revision as of 13:42, 13 May 2013

  • Description: choline dehydrogenase (FAD-dependent), glycine betaine synthesis

Gene name gbsB
Synonyms
Essential no
Product choline dehydrogenase (FAD-dependent)
Function osmoprotection
Gene expression levels in SubtiExpress: gbsB
Metabolic function and regulation of this protein in SubtiPathways:
Stress
MW, pI 43 kDa, 4.912
Gene length, protein length 1209 bp, 403 aa
Immediate neighbours yuaD, gbsA
Sequences Protein DNA Advanced_DNA
Genetic context
GbsB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
GbsB expression.png




























Categories containing this gene/protein

miscellaneous metabolic pathways, coping with hyper-osmotic stress

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU31050

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: An alcohol + NAD+ = an aldehyde or ketone + NADH (according to Swiss-Prot)
  • Protein family: iron-containing alcohol dehydrogenase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Erhard Bremer, University of Marburg, Germany homepage

Your additional remarks

References

Additional publications: PubMed

Tamara Hoffmann, Erhard Bremer
Protection of Bacillus subtilis against cold stress via compatible-solute acquisition.
J Bacteriol: 2011, 193(7);1552-62
[PubMed:21296969] [WorldCat.org] [DOI] (I p)

J Boch, B Kempf, R Schmid, E Bremer
Synthesis of the osmoprotectant glycine betaine in Bacillus subtilis: characterization of the gbsAB genes.
J Bacteriol: 1996, 178(17);5121-9
[PubMed:8752328] [WorldCat.org] [DOI] (P p)