Difference between revisions of "SasA"

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=== Additional information===
 
=== Additional information===
 
 
 
  
 
=The protein=
 
=The protein=
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=References=
 
=References=
'''Additional publications:''' {{PubMed|21926231}}
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<pubmed> 18670626 19447912 18067544 19477419 12207695 11866510 18179421 </pubmed>
 
<pubmed> 18670626 19447912 18067544 19477419 12207695 11866510 18179421 </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 09:05, 6 September 2012

  • Description: (p)ppGpp synthetase, small alarmone synthetase

Gene name ywaC
Synonyms ipa-7d
Essential no
Product (p)ppGpp synthetase
Function ppGpp synthesis independent from stringent response
Gene expression levels in SubtiExpress: ywaC
MW, pI 24 kDa, 6.217
Gene length, protein length 630 bp, 210 aa
Immediate neighbours ywaD, menA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YwaC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YwaC expression.png















Categories containing this gene/protein

metabolism of signalling nucleotides, cell envelope stress proteins (controlled by SigM, V, W, X, Y)

This gene is a member of the following regulons

SigM regulon SigW regulon

The gene

Basic information

  • Locus tag: BSU38480

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s): YjbM

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • transcription is highly upregulated in response to lesions in late-acting teichoic acid synthesis genes tagB, tagD and tagF, and also in response to cell-wall-active compounds like bacitracin or vancomycin PubMed
    • expression is reduced in a SigV mutant PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed