Difference between revisions of "OhrA"

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m (Reverted edits by 134.76.70.252 (talk) to last revision by Jstuelk)
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* '''Operon:''' ''[[ohrA]]'' {{PubMed|9696771}}
 
* '''Operon:''' ''[[ohrA]]'' {{PubMed|9696771}}
  
* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|9696771}}
+
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ohrA_1380978_1381403_1 ohrA] {{PubMed|22383849}}
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* '''Sigma factor:''' [[SigA]] {{PubMed|9696771}}
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  
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** [[OhrR]]: transcription repression {{PubMed|11418552}}
 
** [[OhrR]]: transcription repression {{PubMed|11418552}}
  
* '''Additional information:'''  
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* '''Additional information:'''
  
 
=Biological materials =
 
=Biological materials =

Revision as of 07:28, 13 April 2012

  • Description: peroxiredoxin , protects the cell against organic peroxides

Gene name ohrA
Synonyms yklA
Essential no
Product peroxiredoxin
Function organic peroxide resistance
MW, pI 14 kDa, 5.061
Gene length, protein length 423 bp, 141 aa
Immediate neighbours proA, ohrR
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YklA context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

resistance against oxidative and electrophile stress

This gene is a member of the following regulons

OhrR regulon

The gene

Basic information

  • Locus tag: BSU13140

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: osmC/ohr family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Minsun Hong, Mayuree Fuangthong, John D Helmann, Richard G Brennan
Structure of an OhrR-ohrA operator complex reveals the DNA binding mechanism of the MarR family.
Mol Cell: 2005, 20(1);131-41
[PubMed:16209951] [WorldCat.org] [DOI] (P p)

John D Helmann, Ming Fang Winston Wu, Ahmed Gaballa, Phil A Kobel, Maud M Morshedi, Paul Fawcett, Chris Paddon
The global transcriptional response of Bacillus subtilis to peroxide stress is coordinated by three transcription factors.
J Bacteriol: 2003, 185(1);243-53
[PubMed:12486061] [WorldCat.org] [DOI] (P p)

M Fuangthong, S Atichartpongkul, S Mongkolsuk, J D Helmann
OhrR is a repressor of ohrA, a key organic hydroperoxide resistance determinant in Bacillus subtilis.
J Bacteriol: 2001, 183(14);4134-41
[PubMed:11418552] [WorldCat.org] [DOI] (P p)

U Völker, K K Andersen, H Antelmann, K M Devine, M Hecker
One of two osmC homologs in Bacillus subtilis is part of the sigmaB-dependent general stress regulon.
J Bacteriol: 1998, 180(16);4212-8
[PubMed:9696771] [WorldCat.org] [DOI] (P p)