Difference between revisions of "MurC"

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= [[Categories]] containing this gene/protein =
 
= [[Categories]] containing this gene/protein =
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===Phenotypes of a mutant ===
 
===Phenotypes of a mutant ===
 
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* essential [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
essential [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
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* murC is dispensable in wall-less L-forms {{PubMed|24704074}}
  
 
=== Database entries ===
 
=== Database entries ===
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=== Additional information===
 
=== Additional information===
 
 
 
  
 
=The protein=
 
=The protein=
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* '''Kinetic information:'''
 
* '''Kinetic information:'''
  
* '''Domains:'''  
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* '''[[Domains]]:'''  
  
 
* '''Modification:'''
 
* '''Modification:'''
  
* '''Cofactor(s):'''
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* '''[[Cofactors]]:'''
  
 
* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=murC_3048177_3049475_-1 murC] {{PubMed|22383849}}
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=murC_3048177_3049475_-1 murC] {{PubMed|22383849}}
  
* '''Sigma factor:'''  
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* '''[[Sigma factor]]:'''  
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  
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=References=
 
=References=
  
<pubmed>18063720,8733232 , 16479537 </pubmed>
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<pubmed>18063720,8733232 , 24704074 16479537 </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 13:39, 8 April 2014

  • Description: UDP-N-acetylmuramoyl-L-alanine synthetase

Gene name murC
Synonyms ytxF
Essential yes PubMed
Product UDP-N-acetylmuramoyl-L-alanine synthetase
Function peptidoglycan precursor biosynthesis
Gene expression levels in SubtiExpress: murC
Metabolic function and regulation of this protein in SubtiPathways:
murC
MW, pI 48 kDa, 5.307
Gene length, protein length 1296 bp, 432 aa
Immediate neighbours ytxG, sftA
Sequences Protein DNA DNA_with_flanks
Genetic context
MurC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
MurC expression.png















Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, essential genes

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU29790

Phenotypes of a mutant

  • essential PubMed
  • murC is dispensable in wall-less L-forms PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine (according to Swiss-Prot)
  • Protein family: murCDEF family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References