yxdM

168

ABC transporter (permease)

Locus: BSU_39630

Molecular weight: 70.35 kDa

Isoelectric point: 9.27

Protein length: 622 aa

Gene length: 1869 bp

Function: export of toxic peptides

Product: ABC transporter (permease)

Essential: no

Synonyms: yxdM, apeB

Genomic Context

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List of homologs in different organisms, belongs to COG0577 (Galperin et al., 2021)

Gene

Coordinates: 4,068,550  4,070,418

The protein

Protein family

• ABC-4 integral membrane protein family (according to UniProt)

Structure

• P42424 (AlphaFold)

Paralogous protein(s)

• PsdB

Localization

• cell membrane (according to UniProt)

Expression and Regulation

Operons

• Genes: yxdL-yxdM-yxeA

  Description: PubMed

  Regulation

  • induced by a cationic antimicrobial peptide, LL-37 (YxdJ) PubMed

  Regulatory mechanism

  • YxdJ: activation, PubMed, in yxdJ regulon

Biological materials

Mutant

• MGNA-B705 (yxdM::erm), available at the NBRP B. subtilis, Japan
• BKE39630 (yxdM::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_GGCCCTTTTGTTTCTCGTGA,  downstream forward: _UP4_ATGAACAAGTAAGGGGAGTG
• BKK39630 (yxdM::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_GGCCCTTTTGTTTCTCGTGA,  downstream forward: _UP4_ATGAACAAGTAAGGGGAGTG

References

Reviews

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Original Publications

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