yxdL

168

ABC transporter (ATP-binding protein)

Locus: BSU_39640

Molecular weight: 28.57 kDa

Isoelectric point: 7.36

Protein length: 257 aa

Gene length: 774 bp

Function: export of toxic peptides

Product: ABC transporter (ATP-binding protein)

Essential: no

Synonyms: yxdL, apeA

Genomic Context

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List of homologs in different organisms, belongs to COG1136 (Galperin et al., 2021)

Gene

Coordinates: 4,070,393  4,071,166

The protein

Protein family

• ABC transporter superfamily (according to UniProt)

Domains

• ABC transporter domain (aa 5-243) (according to UniProt)

Structure

• 1L2T (PDB) (from Methanocaldococcus jannaschii, 43% identity) PubMed
• P42423 (AlphaFold)

Paralogous protein(s)

• FtsE, BceA, YknY, YtrE, YvrO, PsdA

Localization

• plasma membrane (according to UniProt)

Expression and Regulation

Operons

• Genes: yxdL-yxdM-yxeA

  Description: PubMed

  Regulation

  • induced by a cationic antimicrobial peptide, LL-37 (YxdJ) PubMed

  Regulatory mechanism

  • YxdJ: activation, PubMed, in yxdJ regulon

Biological materials

Mutant

• MGNA-B704 (yxdL::erm), available at the NBRP B. subtilis, Japan
• BKE39640 (yxdL::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGAAAATCCTCCTTATGG,  downstream forward: _UP4_CTGTCTATGCTGGGGGGAAA
• BKK39640 (yxdL::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGAAAATCCTCCTTATGG,  downstream forward: _UP4_CTGTCTATGCTGGGGGGAAA

References

Reviews

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Original Publications

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