pchR

pchR
168

transcriptional repressor ([wiki|MarR family]), controls the expression of genes involved in pulcherriminic acid biosynthesis

locus
BSU_35080
Molecular weight
19.54 kDa
pI
8.09
Protein length
Gene length
function
control of pulcherriminic acid biosynthesis
product
transcription factor ([wiki|MarR family])
essential
no
synonyms
pchR, yzhA, yvmB

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1846 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,604,993  3,605,502
Phenotypes of a mutant
the mutant tends to acquire suppressor mutations that result in improved growth [Pubmed|28189581]
inactivation of ''[gene|0D555F2AB7DC863E6FF388888308E980514DB719|pchR]'' causes widespread disruption of proteins involved in cellular processes that depend on iron availability, with pleiotropic effects on proteins associated with carbon metabolism, translation, stress response, biosynthesis of cell wall, and sporulation initiation [Pubmed|27542896]
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The protein
Protein family
[wiki|MarR family] of transcriptional regulators [Pubmed|27542896]
[wiki|Domains]
[wiki|HTH marR-type domain] (aa 10-153) (according to UniProt)
Structure
[AF|P40762]
Paralogous protein(s)
[protein|F5A59CE7727E0851652BB4C0144009154AB4978B|yhjH]
Additional information
Proposed consensus sequence for DNA-binding site: GTTYMMYMGTAAAC [Pubmed|27542896]
Expression and Regulation
Operons
genes
[gene|0D555F2AB7DC863E6FF388888308E980514DB719|pchR]-[gene|7F10DEEDEF8B679F4F2C5EAD5752F4E399DB0D57|yvmA]
description
[Pubmed|22383849]
regulation
induced by iron starvation [Pubmed|27542896]
regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|12850135]; [protein|0D555F2AB7DC863E6FF388888308E980514DB719|pchR] auto-repression [Pubmed|27542896], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
[protein|0D555F2AB7DC863E6FF388888308E980514DB719|pchR]: repression, in [regulon|protein:0D555F2AB7DC863E6FF388888308E980514DB719|pchR regulon]
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[gene|0D555F2AB7DC863E6FF388888308E980514DB719|pchR]→[gene|7F10DEEDEF8B679F4F2C5EAD5752F4E399DB0D57|yvmA]

2024-03-17 03:22:19

ghost

38

b657299f070e940cb93d2b357a6dbc9c4a095142

3C740754829F2CCBD865EEAC23614B275ACCD213

Biological materials
Mutant
CS217 (''[gene|0D555F2AB7DC863E6FF388888308E980514DB719|pchR]''::''aphA3'', available in [wiki|Colin Harwood]'s and [wiki|Jörg Stülke]'s lab [Pubmed|27197833]
BKE35080 ([gene|0D555F2AB7DC863E6FF388888308E980514DB719|pchR]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE35080 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATAGGCTACCTTCTTTCTT,  downstream forward: _UP4_TAAACAAAAAGGCGGTGTAC
BKK35080 ([gene|0D555F2AB7DC863E6FF388888308E980514DB719|pchR]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK35080 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATAGGCTACCTTCTTTCTT,  downstream forward: _UP4_TAAACAAAAAGGCGGTGTAC
labs
Sandrine Auger, Micalis Institute, INRA, AgroParisTech, France
References
12850135,22383849,27542896,27197833,38260623

0D555F2AB7DC863E6FF388888308E980514DB719

Page visits: 4901

Time of last update: 2024-03-28 04:36:27

Author of last update: Jstuelk