ganP

ganP
168

galactotriose [wiki|ABC transporter] (permease)

locus
BSU_34150
Molecular weight
46.82 kDa
pI
6.09
Protein length
Gene length
function
uptake of galactotriose
product
galactotriose [wiki|ABC transporter] (permease)
essential
no
synonyms
ganP, yvfL

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1175 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,505,957  3,507,213
Phenotypes of a mutant
a ''[gene|D4A5A878F87EBC14C02824233155CEBACEB41343|ganS]-[gene|75B1FD4AA7612B3B600CB0CE35319A6960536095|ganP]-[gene|676932E7DF143DC9AAAF1F415FB3D14EE25B2C2F|ganQ]-[gene|DBBA549C2D71CF628E92AC7B659EA276E227D742|ganA]-[gene|9DDEF5682B2D145830F33C7A1D5A6EC8527BB405|ganB]'' mutant is impaired in the utilization of galactan [Pubmed|22893383]
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The protein
Protein family
[wiki|Binding-protein-dependent transport system permease family] (according to UniProt)
[wiki|Domains]
[wiki|ABC transmembrane type-1 domain] (aa 187-407) (according to UniProt)
Structure
[PDB|2R6G] (from E. coli, C-terminal domain, aa 165-412, 41% identity) [pubmed|18033289]
[AF|O32261]
Paralogous protein(s)
[protein|EA2DD9892C1128ADCD6C8BC61248EBE45339E6D6|mdxF]
[wiki|Localization]
cell membrane [Pubmed|10092453]
Expression and Regulation
Operons
genes
[gene|D4A5A878F87EBC14C02824233155CEBACEB41343|ganS]-[gene|75B1FD4AA7612B3B600CB0CE35319A6960536095|ganP]-[gene|676932E7DF143DC9AAAF1F415FB3D14EE25B2C2F|ganQ]-[gene|DBBA549C2D71CF628E92AC7B659EA276E227D742|ganA]-[gene|9DDEF5682B2D145830F33C7A1D5A6EC8527BB405|ganB]
description
[Pubmed|9287030]
regulation
induced by galactan (binding of galactobiose to [protein|1F787F70C87DEB221709579122D63C2322A84E56|ganR]) [Pubmed|28617843,27501980]
repressed by glucose ([protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]) [Pubmed|28617843,27501980]
regulatory mechanism
[protein|1F787F70C87DEB221709579122D63C2322A84E56|ganR]: repression, [Pubmed|9287030], in [regulon|protein:1F787F70C87DEB221709579122D63C2322A84E56|ganR regulon]
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [pubmed|28617843], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [pubmed|27501980], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|D4A5A878F87EBC14C02824233155CEBACEB41343|ganS]→[gene|9DDEF5682B2D145830F33C7A1D5A6EC8527BB405|ganB]

2024-02-06 10:09:18

Jstuelk

55

8098d66636fb8292b3a8cdd7bc3488e2a6cd4b3a

CC7DD5B518C2C1EF65E89AEC569B449F25EC1495

Biological materials
Mutant
MGNA-A485 (yvfL::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/485 NBRP B. subtilis, Japan]
BKE34150 ([gene|75B1FD4AA7612B3B600CB0CE35319A6960536095|ganP]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE34150 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACCGTTTTCACCTCTCTTA,  downstream forward: _UP4_TCTTTTAAAGAGGAGGCATA
BKK34150 ([gene|75B1FD4AA7612B3B600CB0CE35319A6960536095|ganP]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK34150 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACCGTTTTCACCTCTCTTA,  downstream forward: _UP4_TCTTTTAAAGAGGAGGCATA
References
10092453,9287030,22893383,27501980,18033289

75B1FD4AA7612B3B600CB0CE35319A6960536095

Page visits: 3086

Time of last update: 2024-03-28 21:30:57

Author of last update: Melvin.boenninger