brxC

brxC
168

monothiol bacilliredoxin, general stress protein

locus
BSU_29760
Molecular weight
12.26 kDa
pI
5.09
Protein length
Gene length
function
removal of bacillithiol from oxidized cytosolic proteins
product
monothiol bacilliredoxin
essential
no
synonyms
ytxJ, csb40

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms

This gene is a member of the following regulons

Gene
Coordinates
3,046,757  3,047,083
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The protein
Catalyzed reaction/ biological activity
removal of bacilliredoxin from oxidized cytosolic proteins, including the glyceraldehyde 3-phosphate dehydrogenases [protein|EB6512177418B1601C6641FB2DEE99C2CD10E671|gapA] and [protein|C1B89BD3DD27CD566018558D3A7845FB451056F0|gapB] [pubmed|33722570]
Protein family
Trx family
[wiki|Domains]
contains a single conserved Cys residue in a motif (TCPIS) reminiscent of that found in monothiol glutaredoxins [Pubmed|20308541]
Structure
[PDB|3IV4] (from Staphylococcus aureus, 41% identity)
[AF|P39914]
Modification
phosphorylation on (Thr-93 OR Ser-94 OR Ser-96 OR Thr-99) [Pubmed|17218307]
Expression and Regulation
Operons
genes
[gene|00A42FDB559BE2647CD682180420A435E2E7035F|facZ]-[gene|43BF293F735ED783D36F33AA4701D57F2AED6657|ytxH]-[gene|8B4E1D087B75B5E77BCB60FF3465270CEB72B028|brxC]
description
[Pubmed|8733232]
regulation
induced by stress ([protein|search|SigB]) [Pubmed|8733232,11544224]
sigma factors
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [Pubmed|8733232,11544224], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]
[protein|DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|sigH]: sigma factor, [Pubmed|8733232], in [regulon|protein:DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|sigH regulon]
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[gene|00A42FDB559BE2647CD682180420A435E2E7035F|facZ]→[gene|8B4E1D087B75B5E77BCB60FF3465270CEB72B028|brxC]

2024-03-15 14:48:21

ghost

50

a0db108502ded191eef0405d77d786ae7bc7abdc

623E0B035BA1319C480A20A9385612A917A73D50

Biological materials
Mutant
MGNA-B527 (ytxJ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1526 NBRP B. subtilis, Japan]
BKE29760 ([gene|8B4E1D087B75B5E77BCB60FF3465270CEB72B028|brxC]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE29760 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGACTCAAGCTCTTCCTT,  downstream forward: _UP4_TAGAAAAAAGCGTCCAGATA
BKK29760 ([gene|8B4E1D087B75B5E77BCB60FF3465270CEB72B028|brxC]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK29760 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGACTCAAGCTCTTCCTT,  downstream forward: _UP4_TAGAAAAAAGCGTCCAGATA
References
11544224,17218307,8733232,20308541,33722570

8B4E1D087B75B5E77BCB60FF3465270CEB72B028

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Time of last update: 2024-03-28 05:49:58

Author of last update: Jstuelk