ytpQ

168

unknown

Locus: BSU_29830

Molecular weight: 30.89 kDa

Isoelectric point: 5.3

Protein length: 269 aa

Gene length: 810 bp

Function: maybe involved in iron homeostasis

Product: unknown

Essential: no

E.C.: null

Synonyms: ytpQ

Genomic Context

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List of homologs in different organisms, belongs to COG4848 (Galperin et al., 2021)

Gene

Coordinates: 3,053,364  3,054,173

Phenotypes of a mutant

• derepression of the Fur and PerR regulons PubMed
• elevated oxidative protein damage upon exposure of the cells to methylglyoxal PubMed
• the ''spx ytpQ'' doulbe mutant shows reduced growth in minimal medium and hypersensitivity to methylglyoxal PubMed

The protein

Protein family

• UPF0354 family (single member, according to UniProt)

Structure

• O34496 (AlphaFold)

Expression and Regulation

Operons

• Genes: ytpP-ytpQ-ytpR

  Description: PubMed

  Regulatory mechanism

  • Spx: activation, PubMed, in spx regulon

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

Biological materials

Mutant

• MGNA-A437 (ytpQ::erm), available at the NBRP B. subtilis, Japan
• BKE29830 (ytpQ::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTTCAAACCGATGTCCT,  downstream forward: _UP4_AAGGATTAGAAAGGATTTTT
• BKK29830 (ytpQ::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTTCAAACCGATGTCCT,  downstream forward: _UP4_AAGGATTAGAAAGGATTTTT

References

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