sweD

sweD
168

cofactor of the [protein|8BF7EB539B53D75BD30BD30ABF27106D6A0B030B|ftsE]-[protein|E22D0F0AC56DC95AFC02E7F55FCD5FAA44B6B490|ftsX] complex

locus
BSU_24930
Molecular weight
13.18 kDa
pI
5.05
Protein length
Gene length
function
control of [protein|4F9D70C4BB4FCA809BEAC341C3F8122FB7FD8872|cwlO] activity in peptidoglycan elongation
product
cofactor of the [protein|8BF7EB539B53D75BD30BD30ABF27106D6A0B030B|ftsE]-[protein|E22D0F0AC56DC95AFC02E7F55FCD5FAA44B6B490|ftsX] complex
essential
no
synonyms
sweD, yqzD

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms

This gene is a member of the following regulons

Gene
Coordinates
2,576,367  2,576,720
Phenotypes of a mutant
synthetically lethal with [protein|321F248C22D7283C0F3323F1F4069E36F8D7FE6C|lytE], this can be suppressed by point mutations in [gene|8BF7EB539B53D75BD30BD30ABF27106D6A0B030B|ftsE] or [gene|E22D0F0AC56DC95AFC02E7F55FCD5FAA44B6B490|ftsX] [pubmed|31437162]
cells are shorter and fatter than wild-type, cells are bent and curved, both phenotypes depend on the presence of [protein|4F9D70C4BB4FCA809BEAC341C3F8122FB7FD8872|cwlO] [pubmed|31437162]
defective in [category|SW.4.1.4|Swarming] motility (prolonged period of immotility prior to [category|SW.4.1.4|Swarming]) [pubmed|35638827]
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The protein
Structure
[AF|O32022]
[wiki|Localization]
cell membrane (integral), C-terminal cytoplasmic domain [pubmed|31437162]
Expression and Regulation
Operons
genes
[gene|5F184E491602D548AAE8E6D598BB742513770F73|sweD]-[gene|0BC657B63EE124B17FDA7914262E706B2CC9ABC1|sweC]
description
[Pubmed|22383849]
regulation
repressed under conditions that trigger sporulation ([wiki|Spo0A]) [Pubmed|14651647]
regulatory mechanism
[protein|2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A]: repression, [Pubmed|14651647], in [regulon|protein:2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A regulon]
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[gene|5F184E491602D548AAE8E6D598BB742513770F73|sweD]→[gene|0BC657B63EE124B17FDA7914262E706B2CC9ABC1|sweC]

2024-03-14 21:09:26

Jstuelk

31

d3c26c5c0ad2b02d64f20f743f9b69d1f54de8a0

AC8611ADAB04045125A5F4EF9942EC21D42A527B

additional information
the mRNA is cleaved by [protein|BAB297D18F94FFA67B8D12A684AB4D1BCDFB4981|RNase III] [PubMed|26883633]
Biological materials
Mutant
MGNA-C483 (yqzD::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2481 NBRP B. subtilis, Japan]
BKE24930 ([gene|5F184E491602D548AAE8E6D598BB742513770F73|sweD]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE24930 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACGTTTCATCACCTTCTAT,  downstream forward: _UP4_AAAGATAATGAGAAGGTGCT
BKK24930 ([gene|5F184E491602D548AAE8E6D598BB742513770F73|sweD]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK24930 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACGTTTCATCACCTTCTAT,  downstream forward: _UP4_AAAGATAATGAGAAGGTGCT
References
14651647,26883633,31437162,35638827,36815589

5F184E491602D548AAE8E6D598BB742513770F73

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Time of last update: 2024-03-28 01:39:02

Author of last update: Jstuelk