ypnP

168

putative damage inducible, Na+ driven multidrug efflux pump

locus: BSU_21710

Molecular weight: 48.31 kDa

pI: 10.05

Protein length: 445 aa

Gene length: 1338 bp

function: unknown

product: putative damage inducible, Na+ driven multidrug efflux pump

essential: no

synonyms: ypnP, dinF

List of homologs in different organisms, belongs to COG0534 (Galperin et al., 2021)

Gene

Coordinates: 2,288,669 → 2,290,006

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The protein

Protein family

• [wiki|MOP exporter family]
• [wiki|multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family] (according to UniProt)

Structure

• [PDB|3VVO] (MATE multidrug exporter from Pyrococcus furiosus, 25% identity) [pubmed|23535598]
• [AF|P54181]

[wiki|Localization]

• cell membrane (according to UniProt)

Expression and Regulation

Operons

• genes: [gene|CA85B14720E86D2E609388D561B56ADA880B2190|ypnP]

  description: (according to [http://dbtbs.hgc.jp/COG/prom/ypnP.html DBTBS]) null

Biological materials

Mutant

• MGNA-A890 (ypnP::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/890 NBRP B. subtilis, Japan]
• BKE21710 (Δ[gene|CA85B14720E86D2E609388D561B56ADA880B2190|ypnP]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE21710 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATCTTTTCTCCTTGTGTTC,  downstream forward: _UP4_TAAGTGAAGCACTGCGAAAA
• BKK21710 (Δ[gene|CA85B14720E86D2E609388D561B56ADA880B2190|ypnP]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK21710 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATCTTTTCTCCTTGTGTTC,  downstream forward: _UP4_TAAGTGAAGCACTGCGAAAA

References

Research papers

• 23535598