motI
168
c-di-GMP receptor protein, inhibits flagellar rotation at high c-di-GMP concentrations
locus
BSU_22910
Molecular weight
24.98 kDa
pI
7.88
function
control of [protein|86C729C7D5ABEE519ADC4A893940600BBB655EF1|motA] activity
product
c-di-GMP receptor protein
essential
no
synonyms
motI, dgrA, ypfA, jofA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG5581 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,397,019 → 2,397,672
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The protein
[wiki|Domains]
contains a C-terminal [wiki|PilZ domain] (aa 98-203) [Pubmed|22821967]
[wiki|Cofactors]
c-di-GMP [Pubmed|22821967]
Structure
[PDB|5VX6] (complex with c-di-GMP) [pubmed|29196522]
[AF|P38491]
Effectors of protein activity
binding of c-di-GMP stimulates the inhibitory interaction with [protein|86C729C7D5ABEE519ADC4A893940600BBB655EF1|motA] [Pubmed|22821967]
[wiki|Localization]
forms [protein|86C729C7D5ABEE519ADC4A893940600BBB655EF1|motA]-dependent spots at the membrane [pubmed|29196522]
Expression and Regulation
Operons
genes
[gene|C194336ED96FA844FFE9FB43BE59ADC5D6DDB3BE|motI]-[gene|3459BA0CDAABC288ADF97B111F78C7EAC184840D|ypfB]-[gene|1ADB6E2C8DC82A242CFEFAD22443D14226F1BA60|cmk]-[gene|7C36409F155E4C91CEE902FE6937571BD0C50128|rpsA]-[gene|E91624382EC3DAABFB3123CDA818B4BEF745ACE6|fni]
description
[pubmed|22383849]
genes
[gene|C194336ED96FA844FFE9FB43BE59ADC5D6DDB3BE|motI]-[gene|3459BA0CDAABC288ADF97B111F78C7EAC184840D|ypfB]-[gene|1ADB6E2C8DC82A242CFEFAD22443D14226F1BA60|cmk]-[gene|7C36409F155E4C91CEE902FE6937571BD0C50128|rpsA]
description
[pubmed|22383849]
Biological materials
Mutant
MGNA-A419 (ypfA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/419 NBRP B. subtilis, Japan]
BKE22910 (Δ[gene|C194336ED96FA844FFE9FB43BE59ADC5D6DDB3BE|motI]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE22910 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGACTTCACTCTTTCGC, downstream forward: _UP4_TAAACATCGGCAAACACTTC
BKK22910 (Δ[gene|C194336ED96FA844FFE9FB43BE59ADC5D6DDB3BE|motI]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK22910 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGACTTCACTCTTTCGC, downstream forward: _UP4_TAAACATCGGCAAACACTTC
References
Reviews
Original Publications
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Time of last update: 2024-04-18 06:28:13
Author of last update: Christoph.elfmann