aimR

aimR
168

transcriptional antiterminator, allows expression of [gene|E32A2B695591C80F5A855F0D728CA75D613F8DB4|aimX], part of the arbitrium peptide-based communication system, phage SP beta lytic/lysogenic regulator

locus
BSU_20860
Molecular weight
45.16 kDa
pI
5.86
Protein length
Gene length
function
control of phage SP beta lysogeny
product
SP beta arbitrium transcription factor
essential
no
synonyms
aimR, yopK

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms

This gene is a member of the following regulons

Gene
Coordinates
2,208,994 → 2,210,154
Phenotypes of a mutant
reduced number of phage particles produced after prophage induction, this can be suppressed by inactivation of [gene|01BE35FB190DDC77BE19C013A8E0D980B132CBE1|yopN] [pubmed|34562384]
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The protein
Catalyzed reaction/ biological activity
activates [gene|E32A2B695591C80F5A855F0D728CA75D613F8DB4|aimX] expression in the apo form (in the absence of [protein|20735BFECA52826F0F4D55843EEE7798F414993C|aimP]) [pubmed|34562384]
binds to the [gene|E32A2B695591C80F5A855F0D728CA75D613F8DB4|aimX] mRNA upstream region to act as antiterminator [pubmed|38177302]
Structure
Apo-form: [PDB|5XYB] ([Pubmed|30224798]), [PDB|5ZW5] ([Pubmed|30323253]), [PDB|6IPX] ([Pubmed|30421358]), [PDB|6HP3]([Pubmed|30745087]), [PDB|6JG5] ([Pubmed|31149347])
Complexed with AimP hexapeptide ([protein|20735BFECA52826F0F4D55843EEE7798F414993C|aimP]): [PDB|5Y24] ([Pubmed|30224798]), [PDB|5ZW6] ([Pubmed|30323253]), [PDB|6IM4] ([Pubmed|30421358]), [PDB|6HP5] ([Pubmed|30745087]), [PDB|6JG9] ([Pubmed|31149347])
Complexed with DNA: [PDB|6HP7] ([Pubmed|30745087]), [PDB|6JG8] ([Pubmed|31149347])
[AF|O31927]
Expression and Regulation
Operons
genes
[gene|CAE7D8E45DA7CDE99D3EA114DF7E368A0A126389|aimR]-[gene|20735BFECA52826F0F4D55843EEE7798F414993C|aimP]
description
[pubmed|22383849]
expression
repressed by [protein|7F82DED7C941BC501B6F810BF6541780AB87EDDD|mrpR]
regulatory mechanism
[protein|7F82DED7C941BC501B6F810BF6541780AB87EDDD|mrpR]: repression, in [regulon|protein:7F82DED7C941BC501B6F810BF6541780AB87EDDD|mrpR regulon]
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Array

2024-03-28 10:00:12

Jstuelk

28

D2DC54A2C3ACA3E43834E682BFD48B5E0755B52F

218FA1DAE15E4035B58D89E3FFE4707CD53666F8

Biological materials
Mutant
BKE20860 (Δ[gene|CAE7D8E45DA7CDE99D3EA114DF7E368A0A126389|aimR]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE20860 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTATTTCCCCTCATTTCT,  downstream forward: _UP4_TAAAGGAGGTGAGACAATGA
BKK20860 (Δ[gene|CAE7D8E45DA7CDE99D3EA114DF7E368A0A126389|aimR]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK20860 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTATTTCCCCTCATTTCT,  downstream forward: _UP4_TAAAGGAGGTGAGACAATGA
References
Research papers
30323253,30224798,30421358,30745087,31149347,34562384,34562385,34572534,22383849,37602373,38177302

CAE7D8E45DA7CDE99D3EA114DF7E368A0A126389

Page visits: 2298

Time of last update: 2024-03-27 14:23:01

Author of last update: Jstuelk