bmrC

bmrC
168

multidrug [wiki|ABC transporter] (ATP-binding protein), also involved in the signalling pathway to activate [protein|search|KinA ]at the onset of [wiki|sporulation]

locus
BSU_09710
Molecular weight
64.94 kDa
pI
6.25
Protein length
Gene length
function
multiple antibiotic resistance
product
multidrug [wiki|ABC transporter ](ATP-binding protein)
essential
no
synonyms
bmrC, yheI

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1132 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,045,318  1,047,075
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The protein
Protein family
[wiki|ABC transporter superfamily] (according to UniProt)
[wiki|Domains]
has both a membrane-spanning and an ATP-binding domain [Pubmed|10092453]
[wiki|ABC transmembrane type-1 domain] (aa 19-304) (according to UniProt)
[wiki|ABC transporter domain] (aa 337-572) (according to UniProt)
Structure
[PDB|7M33] [pubmed|34931066]
[PDB|5MKK] (TmrAB complex from Thermus thermophilus, 35% identity) [pubmed|28069938]
[AF|O07550]
Paralogous protein(s)
[protein|70D7098BEBD5E53B4B9B8C3394FAAF972C65EE22|yknU], [protein|C6B0ACB9D9703DD8141FD7D9D62DB22FB48F458B|yknV], [protein|D5A3C316BD4567A0155F70330E32ACDE18F063FE|ywjA], [protein|E85814EDF232D21A42380D559EAD2CDFB41F19DB|yfiC], [protein|ED1F82463BAA28B67184BFAB5CB23CF26A62999D|bmrA], [protein|0EB4D3E1B9AF39ECCBD79EB559FAE5BB0EE4C156|ygaD], [protein|288CA73D93B1E5106E1C6CE5E7E2E8BE2A6BD3F3|yfiB]
[wiki|Localization]
cell membrane [Pubmed|10092453]
Expression and Regulation
Operons
genes
[gene|E9956A958C66C4114EB974EA6F9BF30CD951034A|bmrB]-[gene|E98074149254BF56648F6CBE56E74B3D7DCD5DB3|bmrX]-[gene|67C0C9EA17EF953554D3D57CD0D285246F50C1AD|bmrC]-[gene|9B2766D2F8892AA17DB480216570C81C33355C3B|bmrD]
description
[Pubmed|25217586]
regulation
[gene|E9956A958C66C4114EB974EA6F9BF30CD951034A|bmrB]-[gene|E98074149254BF56648F6CBE56E74B3D7DCD5DB3|bmrX]-[gene|67C0C9EA17EF953554D3D57CD0D285246F50C1AD|bmrC]-[gene|9B2766D2F8892AA17DB480216570C81C33355C3B|bmrD] expression only occurs during the late-exponential and stationary growth stages ([protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]) [Pubmed|25217586]
RNA processing in the intergenic region between [gene|67C0C9EA17EF953554D3D57CD0D285246F50C1AD|bmrC] and [gene|67C0C9EA17EF953554D3D57CD0D285246F50C1AD|bmrC] (in [gene|E98074149254BF56648F6CBE56E74B3D7DCD5DB3|bmrX]) ([protein|search|Rae1]) [pubmed|37142436]
expression
expression is increased upon depletion of depletion of tRNA maturation factors [gene|57A79AAF00243B5E058FA901D43AA7B55CA33F63|rnpB] or [gene|C40C5D35ED53D343C8200248FCCB010BAB388054|rnz] [pubmed|36840557]
regulatory mechanism
[protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]: repression, [Pubmed|20817675,25217586], in [regulon|protein:E5110D9C36E8C55AFD1419987B14A53232165F20|abrB regulon]
[protein|E9956A958C66C4114EB974EA6F9BF30CD951034A|bmrB]: attenuation, [Pubmed|25217586], in [regulon|protein:E9956A958C66C4114EB974EA6F9BF30CD951034A|bmrB regulon]
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[gene|E9956A958C66C4114EB974EA6F9BF30CD951034A|bmrB]→[gene|9B2766D2F8892AA17DB480216570C81C33355C3B|bmrD]

2024-03-23 18:34:40

Jstuelk

90

5133AE29C8DE1B1184B38190144E212977A8B571

6093E35E651F3CE8574990742E33F0A5554BD884

Biological materials
Mutant
MGNA-B490 (yheI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1489 NBRP B. subtilis, Japan]
BKE09710 ([gene|67C0C9EA17EF953554D3D57CD0D285246F50C1AD|bmrC]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE09710 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATCTATCCCCATCTCCTCA,  downstream forward: _UP4_GCGGAAGAAGGGGGAGCAGG
BKK09710 ([gene|67C0C9EA17EF953554D3D57CD0D285246F50C1AD|bmrC]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK09710 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATCTATCCCCATCTCCTCA,  downstream forward: _UP4_GCGGAAGAAGGGGGAGCAGG
References
Reviews
33450852
Original Publications
19167342,10092453,16487324,25217586,21602923,29507890,28069938,34931066,36840557,37142436

67C0C9EA17EF953554D3D57CD0D285246F50C1AD

Page visits: 4290

Time of last update: 2024-03-28 10:41:22

Author of last update: Jstuelk