niaP

168

nicotinate transporter

Locus: BSU_02950

Molecular weight: 43.55 kDa

Isoelectric point: 9.5

Protein length: 400 aa

Gene length: 1203 bp

Function: uptake of niacin

Product: nicotinate transporter

Essential: no

Synonyms: niaP, yceI

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

Cellular processes, Transporters, Transporters/ other, Transporter for cofactors

Metabolism, Additional metabolic pathways, Biosynthesis of cofactors, Biosynthesis of NAD(P)

Groups of genes, Membrane proteins

List of homologs in different organisms, belongs to COG2814 (Galperin et al., 2021)

This gene is a member of the following regulons

NadR regulon

Gene

Coordinates: 317,725  318,927

Phenotypes of a mutant

more sensitive to nisin PubMed

The protein

Protein family

major facilitator superfamily PubMed
Sugar transporter (TC 2.A.1.1) family (according to UniProt)

Domains

10 membrane-spanning domains PubMed

Structure

4J05 (PDB) (from P. indica, 24% identity) PubMed
O34691 (AlphaFold)

Localization

cell membrane PubMed

Expression and Regulation

Operons

Genes: niaP

Description: PubMed

Regulation

repressed in the presence of nicotinic acid (NadR) PubMed

Regulatory mechanism

NadR: repression, PubMed, in nadR regulon

Biological materials

Mutant

MGNA-C047 (yceI::erm), available at the NBRP B. subtilis, Japan
BKE02950 (niaP::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTGCCAACACCTCTGATA,  downstream forward: _UP4_TAGGAAAAGCACCTCTTAAA
BKK02950 (niaP::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTGCCAACACCTCTGATA,  downstream forward: _UP4_TAGGAAAAGCACCTCTTAAA

References

Reviews

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Original Publications

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