serB

168

phosphoserine phosphatase, catalyzes the last step in serine biosynthesis

Locus: BSU_28940

Molecular weight: 29.36 kDa

Isoelectric point: 4.67

Protein length: 260 aa

Gene length: 783 bp

Function: biosynthesis of serine

Product: phosphoserine phoshatase

Essential: no

Synonyms: serB, ysaA

Genomic Context

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List of homologs in different organisms, belongs to COG1011 (Galperin et al., 2021)

Gene

Coordinates: 2,958,434  2,959,216

Phenotypes of a mutant

• auxotrophic for serine PubMed

The protein

Catalyzed reaction/ biological activity

• phosphoserine - serine + phosphate PubMed

Protein family

• HAD superfamily (according to UniProt)

Structure

• 2GFH (PDB) (from mouse, 32% identity)
• P94512 (AlphaFold)

Paralogous protein(s)

• YfnB

Expression and Regulation

Operons

• Genes: serB

  Description: PubMed

Biological materials

Mutant

• MGNA-A998 serB::erm, available at the NBRP B. subtilis, Japan
• BKE28940 (serB::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGATCTTCTCCTCTGCTT,  downstream forward: _UP4_TAAAAAAAGCATGATCTCTT
• BKK28940 (serB::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGATCTTCTCCTCTGCTT,  downstream forward: _UP4_TAAAAAAAGCATGATCTCTT

References

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