rapE

168

response regulator aspartate phosphatase, dephosphorylates Spo0F-P, control of the phosphorelay

Locus: BSU_25830

Molecular weight: 44.40 kDa

Isoelectric point: 7.31

Protein length: 375 aa

Gene length: 1128 bp

Function: control of sporulation initiation

Product: response regulator aspartate phosphatase

Essential: no

Synonyms: rapE, yqcH

Genomic Context

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Categories containing this gene/protein

Information processing, Protein synthesis, modification and degradation, Protein modification, Protein phosphatases

Information processing, Regulation of gene expression, Transcription factors and their control, Control of two-component response regulators, Response regulator aspartate phosphatase

Information processing, Regulation of gene expression, phosphorelay, Phosphatases controlling the phosphorelay

Information processing, Regulation of gene expression, Quorum sensing

Lifestyles, Sporulation, phosphorelay, Phosphatases controlling the phosphorelay

Prophages and mobile genetic elements, Prophages, Skin element

List of homologs in different organisms

Gene

Coordinates: 2,659,213  2,660,340

The protein

Protein family

RAP family (according to UniProt)

Domains

six tetratrichopeptide repeats (according to UniProt)

Structure

4I9E (PDB) (RapF, 38% identity) PubMed
P45943 (AlphaFold)

Expression and Regulation

Operons

Genes: rapE-phrE

Description: PubMed

Regulation

repressed by glucose (10-fold) (CcpA) PubMed

Regulatory mechanism

CodY: repression, PubMed, in codY regulon
ComA: activation, in comA regulon

Biological materials

Mutant

BKE25830 (rapE::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAAGATATTCACCCTTCCCT,  downstream forward: _UP4_CAAATATCGAAAGGGGAATG
BKK25830 (rapE::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAAGATATTCACCCTTCCCT,  downstream forward: _UP4_CAAATATCGAAAGGGGAATG

References

Reviews

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Original Publications

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