qoxD

qoxD
168

cytochrome aa3 quinol oxidase (subunit IV)

locus
BSU_38140
Molecular weight
13.55 kDa
pI
5.94
Protein length
Gene length
function
respiration
product
cytochrome aa3 quinol oxidase (subunit IV)
essential
no
ec
1.10.3.-
synonyms
qoxD, ipa-40d

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG3125 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,914,315  3,914,689
Visit Sartorius.com Visit Sartorius.com
Advertisement
The protein
Catalyzed reaction/ biological activity
2 quinol + O2 --> 2 quinone + 2 H2O (according to UniProt)
Protein family
cytochrome c oxidase bacterial subunit 4 family (with [protein|28E5AF86CE49D7B0ECBFAF9ED5C1FC65D9F810EA|ctaF], according to UniProt)
Structure
[AF|P34959]
[wiki|Localization]
cell membrane (according to UniProt)
Additional information
the [protein|48A9E1E39838BFFCF12CADF0A8D8E6FFDCA6F175|qoxA]-[protein|CBF2DCFFD8195304F942ECBA8596444F0AC47CC6|qoxB]-[protein|CD4520EF427AEFDCF028AE063BC373FA6DCE379E|qoxC]-[protein|03335DC50CED7B38E2380640AE108ADA09A2CBDF|qoxD] cytochrome aa3 oxidase complex is sensitive to increased intracellular Mn2+ concentrations, this results in the generation of toxic reactive radicals [pubmed|34097790]
Expression and Regulation
Operons
genes
[gene|48A9E1E39838BFFCF12CADF0A8D8E6FFDCA6F175|qoxA]-[gene|CBF2DCFFD8195304F942ECBA8596444F0AC47CC6|qoxB]-[gene|CD4520EF427AEFDCF028AE063BC373FA6DCE379E|qoxC]-[gene|03335DC50CED7B38E2380640AE108ADA09A2CBDF|qoxD]
description
[Pubmed|1316894]
regulation
[protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
regulatory mechanism
stringent response: negative regulation, in [regulon|other_regulator:stringent response|stringent response]
[protein|E15E9F88B0E03FE8834C646369D2F4B4E713EF41|citB]: translation control, [pubmed|], in [regulon|protein:E15E9F88B0E03FE8834C646369D2F4B4E713EF41|citB regulon]
additional information
the presence of an iron-responsive element bound by [wiki|CitB] between ''[wiki|feuA]'' and ''[wiki|feuB]'' suggests iron-dependent regulation by [wiki|CitB] [Pubmed|10468622]
Open in new tab

[gene|48A9E1E39838BFFCF12CADF0A8D8E6FFDCA6F175|qoxA]→[gene|03335DC50CED7B38E2380640AE108ADA09A2CBDF|qoxD]

2024-03-06 23:29:10

ghost

72

528706cf2ce16a4799a79387ef081442d5a898c0

DCA1ED001F8B0E6CA914E7163B3631C2F439B710

Biological materials
Mutant
BKE38140 ([gene|03335DC50CED7B38E2380640AE108ADA09A2CBDF|qoxD]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE38140 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_GTGTTCAGCAGATTTGTTTG,  downstream forward: _UP4_TAATACAAAAAACCCTCTTC
BKK38140 ([gene|03335DC50CED7B38E2380640AE108ADA09A2CBDF|qoxD]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK38140 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_GTGTTCAGCAGATTTGTTTG,  downstream forward: _UP4_TAATACAAAAAACCCTCTTC
References
Reviews
33705278
Original Publications
11073895,1316894,20351111,10551842,10468622,27503613,34097790,36422766

03335DC50CED7B38E2380640AE108ADA09A2CBDF

Page visits: 2158

Time of last update: 2024-03-29 14:41:41

Author of last update: Jstuelk