priA

168

primosomal replication factor Y, part of the replisome, required for survival of DNA damage

Locus: BSU_15710

Molecular weight: 91.16 kDa

Isoelectric point: 8.28

Protein length: 805 aa

Gene length: 2418 bp

Function: DNA replication initiation

Product: primosomal replication factor Y

Essential: yes

E.C.: 3.6.4.-

Synonyms: priA, yloJ

Genomic Context

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List of homologs in different organisms, belongs to COG1198 (Galperin et al., 2021)

Gene

Coordinates: 1,644,068 → 1,646,485

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• binds stalled replication forks and initiates fork restart allowing for chromosomes to be fully duplicated under stressful conditions PubMed
• binds to abasic DNA lesions PubMed

Protein family

• helicase family (according to UniProt)

Domains

• Helicase ATP-binding domain (aa 282-448) (according to UniProt)
• Helicase C-terminal domain (aa 545-699) (according to UniProt)

Structure

• 4NL4 (PDB) (from Klebsiella pneumoniae, 38% identity) PubMed
• P94461 (AlphaFold)

Expression and Regulation

Operons

• Genes: yloC-remA-gmk-yloH-coaBC-priA-defA-fmt-yloM-yloN

  Description

  • PubMed

Additional information

• the mRNA is cleaved by RNase III PubMed

References

Reviews

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Original Publications

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