phoA

phoA
168

alkaline phosphatase A

locus
BSU_09410
Molecular weight
50.11 kDa
pI
9.93
Protein length
Gene length
function
aquisition of phosphate upon phosphate starvation
product
alkaline phosphatase A
essential
no
ec
3.1.3.1
synonyms
phoA, phoAIV

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1785 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,017,083 → 1,018,468
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The protein
Catalyzed reaction/ biological activity
phosphate monoester + H2O --> alcohol + phosphate (according to UniProt)
Protein family
alkaline phosphatase family (with [protein|3B95AB3021280215B6B487A348D78FB5797AEEA6|phoB], according to UniProt)
Structure
[PDB|3A52] (from Shewanella sp., mature protein without signal peptide, 40% identity) [pubmed|20057143]
[AF|P19406]
Paralogous protein(s)
[protein|3B95AB3021280215B6B487A348D78FB5797AEEA6|phoB]
[wiki|Localization]
extracellular (signal peptide) [Pubmed|18957862]
Expression and Regulation
Operons
genes
[gene|E0430C16C41440633647976A0F9183E24268E198|phoA]
description
[Pubmed|16291680]
regulation
expressed under conditions of phosphate limitation ([protein|search|PhoP]) [Pubmed|16291680,8113174]
regulatory mechanism
[protein|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP]: activation, [Pubmed|16291680,8113174], in [regulon|protein:638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8113174], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG]: sigma factor, [Pubmed|15699190], in [regulon|protein:5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG regulon]
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[gene|E0430C16C41440633647976A0F9183E24268E198|phoA]

2024-02-24 07:45:20

ghost

48

c5f909c79db9c85c38e7128cd5bf36305bf1c419

179175A7CC709AA58606A1C79DFA45FC4CC334EF

Biological materials
Mutant
1A767 ( ''phoA''::''cat''), [Pubmed|9426145], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A767&Search=1A767 BGSC]
BKE09410 (Δ[gene|E0430C16C41440633647976A0F9183E24268E198|phoA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE09410 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGCCTCCTTTAATGTATT,  downstream forward: _UP4_TAAAAAGGATGCAGAACGCT
BKK09410 (Δ[gene|E0430C16C41440633647976A0F9183E24268E198|phoA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK09410 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGCCTCCTTTAATGTATT,  downstream forward: _UP4_TAAAAAGGATGCAGAACGCT
labs
[wiki|Marion Hulett], University of Illinois at Chicago, USA [http://www.uic.edu/depts/bios/faculty/hulett/hulettm.shtml Homepage]
References
9593301,10913081,16491025,15699190,18957862,16291680,8113174,25666134,27118079,20057143

E0430C16C41440633647976A0F9183E24268E198

Page visits: 6540

Time of last update: 2024-03-29 08:54:18

Author of last update: Melvin.boenninger