nupC

168

pyrimidine nucleoside transport protein

Locus: BSU_39410

Molecular weight: 42.37 kDa

Isoelectric point: 9.32

Protein length: 393 aa

Gene length: 1182 bp

Function: pyrimidine uptake

Product: pyrimidine nucleoside transport protein

Essential: no

Synonyms: nupC

Genomic Context

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List of homologs in different organisms, belongs to COG1972 (Galperin et al., 2021)

Gene

Coordinates: 4,050,340  4,051,521

The protein

Protein family

• concentrative nucleoside transporter (CNT) (TC 2.A.41) family (with YutK and NupG, according to UniProt)

Structure

• 3TIJ (PDB) (from Vibrio cholerae, 33% identity) PubMed
• P39141 (AlphaFold)

Localization

• membrane protein PubMed

Expression and Regulation

Operons

• Genes: dra-nupC-pdp

  Description: PubMed

  Regulation

  • induced by deoxynucleotides (DeoR) PubMed

  Regulatory mechanism

  • CcpA: repression, PubMed, in ccpA regulon
  • DeoR: repression, PubMed, in deoR regulon

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

Biological materials

Mutant

• BKE39410 (nupC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATGTGTTTCTCCTTTAT,  downstream forward: _UP4_TGAACTTAATCGAAAAGGAT
• BKK39410 (nupC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATGTGTTTCTCCTTTAT,  downstream forward: _UP4_TGAACTTAATCGAAAAGGAT

References

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