mcpC

mcpC
168

membrane-bound chemotaxis receptor for proline, methyl-accepting chemotaxis protein

locus
BSU_13950
Molecular weight
71.93 kDa
pI
5.17
Protein length
Gene length
function
control of chemotaxis to proline, threonine, glycine, serine, lysine, valine and arginine
product
methyl-accepting chemotaxis protein
essential
no
synonyms
mcpC, prg71

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0840 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,463,628  1,465,595
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The protein
Catalyzed reaction/ biological activity
deaminated [protein|8333CD46F704F03A22482CAA98DEFCC945362A10|mcpC] stimulates phosphorylation of [protein|6B3B222E56BF0C95A2371CA5208B5522B44D4689|cheA] [Pubmed|22931217]
responsible for attractant response towards phenol and other aromatics at low (micromolar) concentrations [pubmed|35007157]
[wiki|Domains]
[wiki|Cache domain] (aa 148-225) (according to UniProt)
[wiki|HAMP domain] (aa 298-350) (according to UniProt)
[wiki|Methyl-accepting transducer domain] (aa 369-619) (according to UniProt)
Structure
[PDB|6S1K] (from E. coli, corresponds to aa 279 ... 593, 26% identity) [pubmed|31925330]
[AF|P54576]
Modification
deamination of Gln-609 (by [protein|BE9373BEB682E5F8B0938AAA4ED9B723B357ABAE|cheD]) [Pubmed|22931217], deaminated [protein|8333CD46F704F03A22482CAA98DEFCC945362A10|mcpC] stimulates phosphorylation of [protein|6B3B222E56BF0C95A2371CA5208B5522B44D4689|cheA] [Pubmed|22931217]
Paralogous protein(s)
[protein|E4E1020B799A1B403BDB4847B91B02D64D161AF3|mcpB], [protein|F02E3080214A327E131ECDE0DBC52C57EFDFE2CE|mcpA], [protein|1DE26CDEE952142C1303C822F0E2A63AE09F721B|tlpA], [protein|4CD44AD8FE68516C84889EAA2137828E06B8A30B|tlpB]
[wiki|Localization]
cell membrane [Pubmed|18763711,21515776]
Expression and Regulation
Operons
genes
[gene|8333CD46F704F03A22482CAA98DEFCC945362A10|mcpC]
description
[Pubmed|9353924]
sigma factors
[protein|7024E4162A6D827069F882FDEACA696EBC05DD40|sigD]: sigma factor, [Pubmed|9353924], in [regulon|protein:7024E4162A6D827069F882FDEACA696EBC05DD40|sigD regulon]
additional information
in minimal medium, McpC is present with 2,800 /- 640 molecules per cell [PubMed|21515776]
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[gene|8333CD46F704F03A22482CAA98DEFCC945362A10|mcpC]

2024-03-10 15:19:16

ghost

57

0d33f32e8e0d88b1c29b3fc4906b5afd83edd958

08CBD29FF4F4B939A75DF93779E0C29E04F48E1D

Biological materials
Mutant
DS180 (''mcpC''::''mls'' in NCIB3610) [Pubmed|12864845]
BKE13950 ([gene|8333CD46F704F03A22482CAA98DEFCC945362A10|mcpC]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE13950 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAAACCAATCCCCTCCTAAT,  downstream forward: _UP4_TAATCCAATTACATCCCCAA
BKK13950 ([gene|8333CD46F704F03A22482CAA98DEFCC945362A10|mcpC]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK13950 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAAACCAATCCCCTCCTAAT,  downstream forward: _UP4_TAATCCAATTACATCCCCAA
References
Reviews
35323015
Original Publications
36815589,12864845,15317802,8251536,9353924,15544802,6137212,9721285,2505839,2105313,12603740,23038252,18763711,9721285,21515776,22931217,27899502,31925330,35007157

8333CD46F704F03A22482CAA98DEFCC945362A10

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Time of last update: 2024-03-19 01:36:35

Author of last update: Jstuelk