leuS

leuS
168

Leu-tRNA synthetase

locus
BSU_30320
Molecular weight
91.35 kDa
pI
4.86
Protein length
Gene length
function
translation
product
leucyl-tRNA synthetase
essential
yes
ec
6.1.1.4
synonyms
leuS

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0495 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,102,629 → 3,105,043
Phenotypes of a mutant
essential [Pubmed|12682299]
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The protein
Catalyzed reaction/ biological activity
ATP + L-leucine + tRNALeu --> AMP + diphosphate + L-leucyl-tRNALeu (according to UniProt)
Protein family
[wiki|Class-I aminoacyl-tRNA synthetase family] (according to UniProt)
Structure
[PDB|1H3N] (from Thermus thermophilus, 46.4% identity) [pubmed|10811626]
[PDB|2AJG] (from ''Escherichia coli'', 39% identity, 56% similarity, 22% coverage) [Pubmed|16277600]
[AF|P36430]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|FEC89C6F5A825D925D730965ACBAA06EC5CC4E44|leuS]
description
[Pubmed|1317842]
regulation
induced by leucine limitation ([protein|search|T-box]) [Pubmed|1317842]
regulatory mechanism
T-box: RNA switch, via uncharged tRNA-Leu binding to [wiki|RNA switch], in [regulon|other_regulator:T-box|T-box]
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[gene|FEC89C6F5A825D925D730965ACBAA06EC5CC4E44|leuS]

2024-03-14 22:16:32

ghost

56

dd08af26ea2ea4d66b9e5b11d03bd36b6d64f072

41F916FDEA06CEE3124D6A01D27CCAB610C0D92D

References
Reviews
19258532
Original Publications
1317842,10811626

FEC89C6F5A825D925D730965ACBAA06EC5CC4E44

Page visits: 2077

Time of last update: 2024-03-28 18:02:49

Author of last update: Jstuelk