kapB

168

activator of [protein|2111AC1AE49D1006E10DC127BF5B7A0327DE94A7|kinB], control of the [wiki|phosphorelay]

locus: BSU_31460

Molecular weight: 14.53 kDa

pI: 6.82

Protein length: 128 aa

Gene length: 387 bp

function: control of [wiki|sporulation] initiation

product: activator of [protein|2111AC1AE49D1006E10DC127BF5B7A0327DE94A7|kinB] in the initiation of [wiki|sporulation]

essential: no

synonyms: kapB

List of homologs in different organisms

Gene

Coordinates: 3,231,399  3,231,785

Advertisement

The protein

Structure

• [PDB|1Y71] (from B. cereus, 61% identity)
• [AF|Q08429]

[wiki|Localization]

• cell membrane (according to UniProt)

Expression and Regulation

Operons

• genes: [gene|2111AC1AE49D1006E10DC127BF5B7A0327DE94A7|kinB]-[gene|18867F99B039D20DBCF004BC72E35CF0AE8FE467|kapB]

  description: [Pubmed|8497199]

  regulation

  • induced upon addition of decoyinine (positive [wiki|stringent response]) [Pubmed|23378509]

  regulatory mechanism

  • [protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY]: repression, [Pubmed|12618455], in [regulon|protein:90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY regulon]
  • stringent response: positive regulation, [Pubmed|23378509], in [regulon|other_regulator:stringent response|stringent response]
  • [protein|5A6FBAE6553343092862CB79E150F934978C32A9|sinR]: repression, [pubmed|29321771], in [regulon|protein:5A6FBAE6553343092862CB79E150F934978C32A9|sinR regulon]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8497199], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]

Biological materials

Mutant

• BKE31460 ([gene|18867F99B039D20DBCF004BC72E35CF0AE8FE467|kapB]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE31460 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATCTGTCATCACCTCGCAT,  downstream forward: _UP4_TAACCCAGTCTGACAAAAGA
• BKK31460 ([gene|18867F99B039D20DBCF004BC72E35CF0AE8FE467|kapB]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK31460 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATCTGTCATCACCTCGCAT,  downstream forward: _UP4_TAACCCAGTCTGACAAAAGA

References

• 9426145,12618455,8497199,7592498,29314743