iolR

168

transcriptional repressor of the iol operon, [wiki|DeoR family]

locus: BSU_39770

Molecular weight: 28.25 kDa

pI: 6.33

Protein length: 251 aa

Gene length: 756 bp

function: regulation of myo-inositol catabolism

product: transcriptional repressor

essential: no

synonyms: iolR

List of homologs in different organisms, belongs to COG1349 (Galperin et al., 2021)

Gene

Coordinates: 4,084,799  4,085,554

Phenotypes of a mutant

• inactivation of ''[gene|5F4ABBC8ECAD6F6C10EC39B2B0F0BC73F11522CE|iolR]'' reduces sporulation efficiency to 38% that of wild type cells [Pubmed|26735940]

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The protein

[wiki|Domains]

• [wiki|HTH deoR-type domain] (aa 1-57) (according to UniProt)

Structure

• [AF|P46337]

Effectors of protein activity

• inducer: 2-deoxy-5-keto-D-gluconic acid-6-phosphate

Biological materials

Mutant

• BKE39770 ([gene|5F4ABBC8ECAD6F6C10EC39B2B0F0BC73F11522CE|iolR]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE39770 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATAAAAAACTCCTTCTT,  downstream forward: _UP4_TAACGTTTACAATAGTGTTG
• BKK39770 ([gene|5F4ABBC8ECAD6F6C10EC39B2B0F0BC73F11522CE|iolR]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK39770 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATAAAAAACTCCTTCTT,  downstream forward: _UP4_TAACGTTTACAATAGTGTTG

labs

• [wiki|Yasutaro Fujita], University of Fukuyama, Japan
• [[Ken-ichi Yoshida]], Kobe University, Japan

References

• 18310071,9226270,9887260,9887260,18310071,26735940