folK

168

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase

Locus: BSU_00790

Molecular weight: 18.91 kDa

Isoelectric point: 4.53

Protein length: 167 aa

Gene length: 504 bp

Function: biosynthesis of folate

Product: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase

Essential: yes

E.C.: 2.7.6.3

Synonyms: folK

Genomic Context

Hide small RNAsZoom:

List of homologs in different organisms, belongs to COG0801 (Galperin et al., 2021)

Gene

Coordinates: 86,946 → 87,449

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• 6-hydroxymethyl-7,8-dihydropterin + ATP --> (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H⁺ (according to UniProt)

Protein family

• HPPK family (single member, according to UniProt)

Structure

• 8SK1 (PDB) (from B. anthracis, 58.5% identity)
• 1IM6 (PDB) (from Escherichia coli, 47% identity, 61% similarity) PubMed
• P29252 (AlphaFold)

Expression and Regulation

Operons

• Genes: pabB-pabA-pabC-sul-folB-folK-yazB-dusB1-lysS

  Description: PubMed

  Regulation

  • translation repressed by tryptophan (MtrB) PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

References

Reviews

Loading

Original Publications

Loading