FadH

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  • Description: 2,4-dienoyl-CoA reductase

Gene name fadH
Synonyms ykuF
Essential no
Product 2,4-dienoyl-CoA reductase
Function fatty acid degradation
Gene expression levels in SubtiExpress: fadH
Metabolic function and regulation of this protein in SubtiPathways:
fadH
MW, pI 26 kDa, 6.495
Gene length, protein length 762 bp, 254 aa
Immediate neighbours ykuE, fadG
Sequences Protein DNA DNA_with_flanks
Genetic context
YkuF context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
FadH expression.png




























Categories containing this gene/protein

utilization of lipids

This gene is a member of the following regulons

FadR regulon

The gene

Basic information

  • Locus tag: BSU14060

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH (according to Swiss-Prot)
  • Protein family: 2,4-dienoyl-CoA reductase subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
    • induced in the presence of long-chain fatty acids (FadR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Yasutaro Fujita, Hiroshi Matsuoka, Kazutake Hirooka
Regulation of fatty acid metabolism in bacteria.
Mol Microbiol: 2007, 66(4);829-39
[PubMed:17919287] [WorldCat.org] [DOI] (P p)

Hiroshi Matsuoka, Kazutake Hirooka, Yasutaro Fujita
Organization and function of the YsiA regulon of Bacillus subtilis involved in fatty acid degradation.
J Biol Chem: 2007, 282(8);5180-94
[PubMed:17189250] [WorldCat.org] [DOI] (P p)