fabD

168

malonyl CoA-acyl carrier protein transacylase

Locus: BSU_15900

Molecular weight: 33.88 kDa

Isoelectric point: 4.51

Protein length: 317 aa

Gene length: 954 bp

Function: fatty acid biosynthesis

Product: malonyl CoA-acyl carrier protein transacylase

Essential: yes

E.C.: 2.3.1.39

Synonyms: fabD, ylpE

Genomic Context

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List of homologs in different organisms, belongs to COG0331 (Galperin et al., 2021)

Gene

Coordinates: 1,663,567 → 1,664,520

Phenotypes of a mutant

• essential PubMed
• enhanced colony wrinkling upon knockdown PubMed

The protein

Catalyzed reaction/ biological activity

• holo-[ACP] + malonyl-CoA --> CoA + malonyl-[ACP] (according to UniProt)

Protein family

• fabD family (with PksC and PksE, according to UniProt)

Structure

• 1MLA (PDB) (the enzyme from E. coli) PubMed
• P71019 (AlphaFold)

Expression and Regulation

Operons

• Genes: fapR-plsX-fabD-fabG-acpA

  Description: PubMed

  Regulation

  • ''FapR'': repressed in the absence of malonyl-CoA or malonyl-ACP (FapR) PubMed
  • expression is reduced in motile cells as compared to non-motile cells PubMed

  Regulatory mechanism

  • FapR: repression, PubMed, in fapR regulon
  • ComA: activation, (ComA) PubMed, in comA regulon

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

References

Reviews

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Original Publications

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