dltB

168

D-alanine transfer from [protein|862D977CF1E185597329A1EF0915485F72482A03|dltC] to undecaprenol-phosphate, alanylation of teichoic acid provides some resistance against positively charged antimicrobial peptides

locus: BSU_38510

Molecular weight: 46.58 kDa

pI: 9.94

Protein length: 395 aa

Gene length: 1188 bp

function: biosynthesis of teichoic acid

product: D-alanine transfer from [protein|862D977CF1E185597329A1EF0915485F72482A03|dltC] to undecaprenol-phosphate

essential: no

synonyms: dltB, ipa-4r

List of homologs in different organisms, belongs to COG1696 (Galperin et al., 2021)

Gene

Coordinates: 3,953,783  3,954,970

Phenotypes of a mutant

• more sensitive to nisin [Pubmed|23980836]

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The protein

Protein family

• Membrane-bound acyltransferase family (single member, according to UniProt)

Structure

• [PDB|6BUI] (from Streptococcus thermophilus) [pubmed|30283133]
• [PDB|6BUG] ([protein|search|DtlB]-[protein|862D977CF1E185597329A1EF0915485F72482A03|dltC] complex from Streptococcus thermophilus) [pubmed|30283133]
• [PDB|6BUH] ([protein|search|DtlB]-[protein|862D977CF1E185597329A1EF0915485F72482A03|dltC] complex from Streptococcus thermophilus) [pubmed|30283133]
• [AF|P39580]

[wiki|Localization]

• cytoplasma membrane [Pubmed|30283133]

Biological materials

Mutant

• BKE38510 ([gene|1B9BAEBE029BE9D4AD7E49C38B1E6DB5E8F4D4D3|dltB]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE38510 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CGTCATACAAGAACCTCTTC,  downstream forward: _UP4_CACCATTAAAGGAGATTAGA
• BKK38510 ([gene|1B9BAEBE029BE9D4AD7E49C38B1E6DB5E8F4D4D3|dltB]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK38510 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CGTCATACAAGAACCTCTTC,  downstream forward: _UP4_CACCATTAAAGGAGATTAGA

References

Reviews

• 24819367

Original Publications

• 14762009,12028417,7797557,18763711,23980836,21856855,21926231,30283133,37308592