cotE

cotE
168

outer spore coat morphogenetic protein, controls the assembly of the outer spore coat layer

locus
BSU_17030
Molecular weight
20.83 kDa
pI
4.14
Protein length
Gene length
function
assembly of the outer spore coat
product
spore coat morphogenetic protein
essential
no
synonyms
cotE

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG5880 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,775,067  1,775,612
Phenotypes of a mutant
mis-assembly of the outer spore coat [Pubmed|22171814]
inactivation of ''[gene|825AD8D4315A85CD384F9AF6AD894E38E57C88F7|cotE]'' reduces sporulation efficiency to 49.1% that of wild type cells [Pubmed|26735940]
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The protein
Catalyzed reaction/ biological activity
assembly of the [protein|9C59B51FC19FC83BD14272008BD441833DD1738E|cotC]-[protein|EB690FA075EAC3E298C47AED082B5FC21E8F8F46|cotU] complex [Pubmed|20023017,18065538]
Protein family
cotE family (single member, according to UniProt)
Structure
[AF|P14016]
[wiki|Localization]
encircles the forespore with a biased accumulation on the mother cell-proximal face of the forespore  [Pubmed|23267091,22463703]
outer spore coat, localization depends on [protein|A25C1530DA7BB007A288E525404E9F775E219FE8|spoIVA] [Pubmed|22773792,22171814]
Expression and Regulation
Operons
genes
[gene|825AD8D4315A85CD384F9AF6AD894E38E57C88F7|cotE]
description
[Pubmed|8760914]
regulation
expressed during sporulation in the mother cell ([protein|search|SigE], [protein|search|SigK], [protein|search|GerE]) [Pubmed|1691789,15383836]
regulatory mechanism
[protein|19228BAD44E6DA3DE908DC390FDF628C18D94E65|gerE]: repression, [Pubmed|15383836], in [regulon|protein:19228BAD44E6DA3DE908DC390FDF628C18D94E65|gerE regulon]
sigma factors
[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]: sigma factor, [Pubmed|15699190,1691789], in [regulon|protein:3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE regulon]
[protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK]: sigma factor, [Pubmed|1691789], in [regulon|protein:24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK regulon]
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[gene|825AD8D4315A85CD384F9AF6AD894E38E57C88F7|cotE]

2024-02-29 08:20:26

ghost

41

df5e14a1265e3e2e508fd6b0e9f2d3f90863fdc2

02BCF0CE206BD81EBBAD019076E714D6C44C8C64

Biological materials
Mutant
1S105 ( ''cotE''::''cat''), [Pubmed|3139490], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S105&Search=1S105 BGSC]
BKE17030 ([gene|825AD8D4315A85CD384F9AF6AD894E38E57C88F7|cotE]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE17030 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTCCGGCATGCCTCCTTG,  downstream forward: _UP4_TAAAAAAGGGACTAGGGGAG
BKK17030 ([gene|825AD8D4315A85CD384F9AF6AD894E38E57C88F7|cotE]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK17030 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTCCGGCATGCCTCCTTG,  downstream forward: _UP4_TAAAAAAGGGACTAGGGGAG
labs
[wiki|Arthur Aronson], Purdue University, West Lafayette, USA [http://wwwdev.gradschool.purdue.edu/PULSe/faculty.cfm?fid=5&range=0 homepage]
[wiki|Adriano Henriques], Lisbon, Portugal [http://www.itqb.unl.pt/research/biology/microbial-development homepage]
References
Reviews
22192522,23202530,27227299
Original Publications
8748030,17720779,10559171,8760914,15699190,7592342,3139490,8299942,1691789,12644503,17172339,19304857,11737650,12107147,20023017,18065538,22773792,15383836,22171814,23064347,23178679,23267091,22463703,21821751,24086406,25259857,25872412,26484546,26821119,26735940,27320701,28870294,30168214,31871031,33573199,33596081

825AD8D4315A85CD384F9AF6AD894E38E57C88F7

Page visits: 4725

Time of last update: 2024-03-19 04:49:59

Author of last update: Jstuelk