cheV

cheV
168

modulation of CheA activity in response to attractants

locus
BSU_14010
Molecular weight
34.48 kDa
pI
4.62
Protein length
Gene length
function
control of CheA activity
product
CheA modulator
essential
no
synonyms
cheV

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0835 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,473,605  1,474,516
Phenotypes of a mutant
''[gene|56E391BD4C154A603FFD06CEC7BC5615AAC5AD04|cheV] [gene|887D84520DF3D5F22DED525C1C17130EDE60DC36|cheW]'' double mutants exhibit complete loss of chemotaxis [Pubmed|21098025]
not essential for pellicle biofilm formation, but mutant is outcompeted by the wild-type strain when competed during pellicle formation [Pubmed|26122431]
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The protein
[wiki|Domains]
N-terminal [protein|887D84520DF3D5F22DED525C1C17130EDE60DC36|cheW]-like domain, C-terminal two-component receiver domain [Pubmed|11553614]
[wiki|Response regulatory domain] (aa 176-302) (according to UniProt)
CheW-like domain (aa 16-154) (according to UniProt)
Structure
[AF|P37599]
Modification
the C-terminal two-component receiver domain is phosphorylated on a Asp residue by [protein|6B3B222E56BF0C95A2371CA5208B5522B44D4689|cheA] [Pubmed|11553614]
Paralogous protein(s)
[protein|887D84520DF3D5F22DED525C1C17130EDE60DC36|cheW], (N-terminal domain of CheV)
[wiki|Localization]
forms lateral clusters (phosphorylated form), but in the presence of high asparagine concentration (non-phosphorylated form) there is a reversible re-localization to the poles of the cell [Pubmed|21098025]
Expression and Regulation
Operons
genes
[gene|56E391BD4C154A603FFD06CEC7BC5615AAC5AD04|cheV]
description
[Pubmed|8169223]
sigma factors
[protein|7024E4162A6D827069F882FDEACA696EBC05DD40|sigD]: sigma factor, [Pubmed|8169223], in [regulon|protein:7024E4162A6D827069F882FDEACA696EBC05DD40|sigD regulon]
additional information
in minimal medium, CheV is present with 7,500 /- 2,000 molecules per cell [PubMed|21515776]
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[gene|56E391BD4C154A603FFD06CEC7BC5615AAC5AD04|cheV]

2024-02-22 11:37:19

ghost

38

718351b20b41aaf0d7de382be7cd320ea7e5e350

5C876D087D1FDBC5C5A8FE0B7E5CCF1B40A4A909

Biological materials
Mutant
DS70 (''cheV''::''mls'' in NCIB3610) [Pubmed|12864845]
BKE14010 ([gene|56E391BD4C154A603FFD06CEC7BC5615AAC5AD04|cheV]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE14010 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAATTCAATCCCTCGCTATT,  downstream forward: _UP4_TAAATAAAAACAGCCGTTGC
BKK14010 ([gene|56E391BD4C154A603FFD06CEC7BC5615AAC5AD04|cheV]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK14010 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAATTCAATCCCTCGCTATT,  downstream forward: _UP4_TAAATAAAAACAGCCGTTGC
References
Reviews
18774298
Original Publications
12864845,26122431,8169224,8169223,11553614,14731274,21098025,21515776,26844549

56E391BD4C154A603FFD06CEC7BC5615AAC5AD04

Page visits: 2960

Time of last update: 2024-03-19 03:30:50

Author of last update: Melvin.boenninger