bsrB

168

6S RNA, important for timing of [wiki|sporulation]

locus: BSU_misc_RNA_32

Gene length: 187 bp

function: antagonist of [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]

product: 6S RNA

essential: no

ec: null

synonyms: bsrB, 6S-2 RNA

Gene

Phenotypes of a mutant

• increased [wiki|biofilm formation] (in undomesticated strains) [pubmed|32862759]

RNA

Catalyzed reaction/ biological activity

• binds to [wiki|RNA polymerase] in [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]-dependent manner to repress transcription from a subgroup of promoters [pubmed|16336121]

Structure

• [PDB|5VT0] (E. coli 6S RNA in complex with [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]-containing [wiki|RNA polymerase] holoenzyme) [pubmed|28988932]

additional information

• paralog: [gene|A0E4AC7E74B5374198D047589629DA96A681CAF4|bsrA]

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The protein

Structure

• [PDB|5VT0] (E. coli 6S RNA in complex with [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]-containing [wiki|RNA polymerase] holoenzyme) [pubmed|28988932]

Expression and Regulation

Operons

• genes: [gene|E85341621B3835F63F07C506E08B73A92E588B1F|bsrB]

  description: [Pubmed|22383849]

• genes: [gene|E85341621B3835F63F07C506E08B73A92E588B1F|bsrB]-[gene|E6EA8098E37A4A2F7370920AC1A500EE4319AAA2|recQ]-[gene|BEBA71A2EF56DAEAF80924856DA68124805BB158|yocH]

  description: [Pubmed|22383849]

additional information

• degradation is initiated by [protein|3EB289D0F58A58C693AB588798EE66A731341999|RNase J1] [pubmed|37369528]

References

Reviews

• 17714443,16336121,24786589,29916345

Research papers

• 21881410,24464747,25483037,25576829,26873600,28988932,32862759,37369528,38348908