kinA
168
two-component sensor kinase, phosphorylates Spo0F, part of the phosphorelay
Locus
BSU_13990
Molecular weight
68.99 kDa
Isoelectric point
5.49
Function
initiation of sporulation
Product
two-component sensor kinase
Essential
no
Synonyms
kinA, spoIIF, spoIIJ, gsiC, scoD
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG5805 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,470,026 → 1,471,846
The protein
Catalyzed reaction/ biological activity
autophosphorylation, phosphorylation of Spo0F
ATP + protein L-histidine --> ADP + protein N-phospho-L-histidine (according to UniProt)
three tandem PAS domains in the N-terminal region of KinA, the second PAS domain is the major N-terminal determinant of KinA dimerization PubMed
the first PAS domain is required for NAD(+) binding PubMed
3 PAS domains (aa 3-73, aa 140-214, aa 265-335) (according to UniProt)
2 PAC domains (aa 77-116, aa 218-255) (according to UniProt)
Histidine Kinase domain (aa 402-606) (according to UniProt)
Structure
2VLG (PDB) (PAS domain)
Modification
autophosphorylation on a His residue
Effectors of protein activity
cytoplasm
Expression and Regulation
Operons
Genes
Description
Regulation
Regulatory mechanism
stringent response: positive regulation, in stringent response
Sigma factors
Additional information
promoter-up mutations or high artificial expression that render ''kinA'' independent from SigH, allow sporulation at high salinity PubMed
Biological materials
Mutant
References
Reviews
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Original Publications
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Time of last update: 2025-01-18 00:11:59
Author of last update: Jstuelk