recR

recR
168

required for the formation of [protein|A44D4677FB70BE8F554BF1001A500F817C7DA95F|recA] DNA repair centers

locus
BSU_00210
Molecular weight
21.83 kDa
pI
5.3
Protein length
Gene length
function
[category|SW.3.1.5|DNA repair/ recombination]
product
formation of [protein|A44D4677FB70BE8F554BF1001A500F817C7DA95F|recA] DNA repair centers
essential
no
synonyms
recR, recM

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0353 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
28,867 → 29,463
Phenotypes of a mutant
drastically reduced survival of mature dormant spores after exposure to ultrahigh vacuum desiccation and ionizing radiation that induce single strand (ss) DNA nicks and double-strand breaks (DSBs) [Pubmed|24285298]
Visit Sartorius.com Visit Sartorius.com
Advertisement
The protein
Catalyzed reaction/ biological activity
required for the formation of [protein|A44D4677FB70BE8F554BF1001A500F817C7DA95F|recA] DNA repair centers (together with [protein|80E6F156764FF30300D034EE6FB44F2DB8338AF3|recO]) [Pubmed|24891441]
Protein family
RecR family (single member, according to UniProt)
[wiki|Domains]
[wiki|TOPRIM domain] (aa 80-175) [Pubmed|9722641]
Structure
[PDB|2V1C] (the [protein|BEBAF1EB53EBB3E7558BB5FE73C418B50000FA29|recR]-[protein|80E6F156764FF30300D034EE6FB44F2DB8338AF3|recO] complex from ''Deinococcus radiodurans'', [protein|BEBAF1EB53EBB3E7558BB5FE73C418B50000FA29|recR]: 52% identity, 78% similarity, [protein|80E6F156764FF30300D034EE6FB44F2DB8338AF3|recO]: 30%/ 58%)  [Pubmed|17581636]
[AF|P24277]
[wiki|Localization]
cytoplasm (homogeneous) [Pubmed|16479537]
Expression and Regulation
Operons
genes
[gene|73D063EDC412F7F28DA27C986ECCCD1C4A1F6618|dnaX]-[gene|9AFCEFE83560B1E2B1FFD7CFD2E4F17FAE137889|yaaK]-[gene|BEBAF1EB53EBB3E7558BB5FE73C418B50000FA29|recR]-[gene|C5127208E7562F09249112240F0BE8C582B2E5AD|yaaL]-[gene|CB5D3A2E5BEE336539BEB2D7C5D9C3A63C78FD01|bofA]
description
[Pubmed|22383849]
Open in new tab

[gene|73D063EDC412F7F28DA27C986ECCCD1C4A1F6618|dnaX]→[gene|CB5D3A2E5BEE336539BEB2D7C5D9C3A63C78FD01|bofA]

2024-03-13 23:00:33

Jstuelk

103

1a32cdecddaee24171f48459041fdcb062bafc36

7EC4B7D4D9D0E5E8848420FD5562059E4207233C

additional information
the mRNA is very stable (> 15 min) [pubmed|12884008]
Biological materials
Mutant
BKE00210 (Δ[gene|BEBAF1EB53EBB3E7558BB5FE73C418B50000FA29|recR]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE00210 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGTTCTTTTATCCCCCTA,  downstream forward: _UP4_TTGTAAGGAGGAAAAAGCGA
BKK00210 (Δ[gene|BEBAF1EB53EBB3E7558BB5FE73C418B50000FA29|recR]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK00210 BGSC] and in [wiki|Jörg Stülke]'s lab,  [Pubmed|28189581], upstream reverse: _UP1_CATGTTCTTTTATCCCCCTA,  downstream forward: _UP4_TTGTAAGGAGGAAAAAGCGA
References
Reviews
22933559,32286623,38052445
Original Publications
12884008,17581636,16479537,24285298,24285298,24891441,9157236,9108290,8419343,9722641

BEBAF1EB53EBB3E7558BB5FE73C418B50000FA29

Page visits: 5238

Time of last update: 2024-03-27 19:45:26

Author of last update: Jstuelk