araE

168

L-arabinose permease (proton symporter)

Locus: BSU_33960

Molecular weight: 50.25 kDa

Isoelectric point: 9.26

Protein length: 464 aa

Gene length: 1395 bp

Function: uptake of arabinose, galactose and xylose

Product: L-arabinose permease

Essential: no

Synonyms: araE, yvbR

Genomic Context

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List of homologs in different organisms, belongs to COG2814 (Galperin et al., 2021)

Gene

Coordinates: 3,484,072  3,485,466

The protein

Catalyzed reaction/ biological activity

• transports arabinose, and also xylose and galactose PubMed

Protein family

• major facilitator superfamily (according to UniProt)
• Sugar transporter (TC 2.A.1.1) family (according to UniProt)

Structure

• 4JA4 (PDB) (the xylose transporter XylE from E. coli, 39% identity, 68% similarity) PubMed
• P96710 (AlphaFold)

Paralogous protein(s)

• YwtG, YfiG, YncC, CsbC, IolT

Localization

• cell membrane (according to Swiss-Prot)

Expression and Regulation

Operons

• Genes: araE

  Description: PubMed

  Regulation

  • induced by arabinose (AraR) PubMed

  Regulatory mechanism

  • CcpA: repression, PubMed, in ccpA regulon
  • AraR: repression, PubMed, in araR regulon

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

Biological materials

Mutant

• BKE33960 (araE::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTCCCTGCCCTCCCGAA,  downstream forward: _UP4_TGAAAACGCTTTAATGAAAC
• BKK33960 (araE::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTCCCTGCCCTCCCGAA,  downstream forward: _UP4_TGAAAACGCTTTAATGAAAC

References

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