pbpB
168
class B penicillin-binding protein 2B, Pbp2B, works together with FtsW in the divisome in septal cell wall synthesis
Locus
BSU_15160
Molecular weight
79.12 kDa
Isoelectric point
9.23
Function
septation, cell division
Product
penicillin-binding protein 2B, member of the divisome
Essential
yes
Synonyms
pbpB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0768 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,581,947 → 1,584,097
Phenotypes of a mutant
essential PubMed
deletion of the PASTA domains is possible, results in impaired cell division and heat sensitivity PubMed
The protein
Catalyzed reaction/ biological activity
assembly of the cell division complex (this is the reason for PbpB essentiality) PubMed
Protein family
transpeptidase family (according to UniProt)
contains two C-terminal PASTA domains (aa 598-657, aa 658-714) (according to UniProt)
Structure
1RP5 (PDB) (PBP 2x from Streptococcus pneumoniae, 32% identity) PubMed
Paralogous protein(s)
Expression and Regulation
Operons
Biological materials
Two-hybrid system
B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Jeff Errington lab
FLAG-tag construct
GP2003 pbpB-3xFLAG spec (based on pGP1331), available in Jörg Stülke's lab
GFP fusion
Labs working on this gene/protein
Jeff Errington, Newcastle University, UK homepage
References
Reviews
Loading
Original Publications
Loading
Page visits: 7810
Time of last update: 2025-04-08 20:28:35
Author of last update: Jstuelk