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rpsD
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rpsD
168

ribosomal protein

locus
BSU_29660
Molecular weight
22.69 kDa
pI
10.24
Protein length
Gene length
function
translation
product
ribosomal protein S4 (BS4)
essential
yes
synonyms
rpsD

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0522

This gene is a member of the following regulons

Gene
Coordinates
3,035,730  3,036,332
Phenotypes of a mutant
essential [Pubmed|23002217,12682299]
The protein
Protein family
[wiki|S4 RNA-binding domain] superfamily (according to http://www.ebi.ac.uk/interpro/entry/IPR036986 Interpro)
universal [wiki|ribosomal protein] uS4 family (single member, according to UniProt)
[wiki|Domains]
[wiki|S4 RNA-binding domain] (aa 92-155) (according to UniProt)
Structure
[PDB|1C06] (Geobacillus stearothermophilus)
[PDB|3J9W] (the [wiki|ribosome]) [Pubmed|25903689]
Expression and Regulation
Operons
genes
[gene|789D08564463542B8D96FC12F408549A669703CE|rpsD]
description
[Pubmed|1699930]
regulation
autorepression of ''rpsD'' expression upon binding of excess [protein|789D08564463542B8D96FC12F408549A669703CE|rpsD] to a [wiki|RNA switch] in the untranslated region of the ''rpsD'' mRNA [Pubmed|27120414,23611891,1906866]
expression is reduced in motile cells as compared to non-motile cells [pubmed|33782055]
regulatory mechanism
stringent response: negative regulation, in [regulon|other_regulator:stringent response|stringent response]
[protein|789D08564463542B8D96FC12F408549A669703CE|rpsD]: autorepression, [pubmed|27120414,23611891,1906866], in [regulon|protein:789D08564463542B8D96FC12F408549A669703CE|rpsD regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|1699930], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
term-seq has identified a potential novel regulatory RNA element including an intrinsic transcription terminator upstream of ''rpsD'' [Pubmed|27120414]
the [wiki|RNA switch] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]
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[gene|789D08564463542B8D96FC12F408549A669703CE|rpsD]

2021-09-10 21:58:57

Jstuelk

7

52079A1F3A15425C8CCFFBF2F6BA2A9F8034F778

0D5D0DD6F002440DF27B5EB7D3A64075B74C9A1F

References
1699930,2121712,6420647,1400226,1906866,19653700,11489846,23611891,23002217,25548247,25548248,26115952,25903689,27120414,29794222,33782055

789D08564463542B8D96FC12F408549A669703CE

Page visits: 2531

Time of last update: 2021-09-19 10:26:20

Author of last update: Jstuelk