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dapG
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dapG
168

aspartokinase I (alpha and beta subunits)

locus
BSU_16760
Molecular weight
42.82 kDa
pI
5.71
Protein length
Gene length
function
biosynthesis of lysine and peptidoglycan
product
aspartokinase I (alpha and beta subunits)
essential
yes
ec
2.7.2.4
synonyms
dapG, lssD

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0527

This gene is a member of the following regulons

Gene
Coordinates
1,747,123  1,748,337
Phenotypes of a mutant
essential [Pubmed|28189581]
The protein
Catalyzed reaction/ biological activity
ATP + L-aspartate --> 4-phospho-L-aspartate + ADP (according to UniProt)
Protein family
aspartokinase family (with [protein|F7B947938FB40E54D89A719E9610C5A4AA400674|lysC] and [protein|548E92526BC00999031D6EDE43FE061CE0448AFC|thrD], according to UniProt)
[wiki|Domains]
[wiki|ACT domain] (aa 344-404) (according to UniProt)
Structure
[PDB|1SFT] (from ''Geobacillus stearothermophilus'', 57% identity) [Pubmed|9063881]
Effectors of protein activity
inhibited by diaminopimelic acid [Pubmed|2152900]
Paralogous protein(s)
[protein|F7B947938FB40E54D89A719E9610C5A4AA400674|lysC]
Expression and Regulation
Operons
genes
[gene|564A2F43F8AABE97FC8F0B1B3382A9F31F02FA18|asd]-[gene|6D6718AC72C9D86EDE16B191EDAB3ABA488B689B|dapG]-[gene|00B4CA4E25858A56F9D4E0ADEE2643F203FEC613|dapA]
description
[Pubmed|8098035]
sigma factors
[protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK]: sigma factor, [Pubmed|15699190,8098035], in [regulon|protein:24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK regulon]
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8098035], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Open in new tab

[gene|564A2F43F8AABE97FC8F0B1B3382A9F31F02FA18|asd]→[gene|00B4CA4E25858A56F9D4E0ADEE2643F203FEC613|dapA]

2021-09-04 22:16:31

ghost

7

26b99709bb2d46d49ca998bee33208e722bad3f7

5716FEABC6E16C3675FEA484CEBA95D8F93F13D1

genes
[gene|3DA80060554B78E9DC2189CECB78680095B08B32|spoVFA]-[gene|4D93A13DB9DC55A49525BFF4FD589F4FF67D50E8|spoVFB]-[gene|564A2F43F8AABE97FC8F0B1B3382A9F31F02FA18|asd]-[gene|6D6718AC72C9D86EDE16B191EDAB3ABA488B689B|dapG]-[gene|00B4CA4E25858A56F9D4E0ADEE2643F203FEC613|dapA]
description
[Pubmed|8098035]
regulation
expressed late during sporulation in the mother cell ([protein|search|SigK]) [Pubmed|15699190,8098035]
sigma factors
[protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK]: sigma factor, [Pubmed|15699190,8098035], in [regulon|protein:24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK regulon]
Open in new tab

[gene|3DA80060554B78E9DC2189CECB78680095B08B32|spoVFA]→[gene|00B4CA4E25858A56F9D4E0ADEE2643F203FEC613|dapA]

2021-09-04 22:16:31

ghost

6

9f1758bf801d23548827e9d03f6ca9d0c2e6746d

C373CB045AB9232B86B60761B90C3510E98A06A8

References
Reviews
19946135,22079167
Original Publications
8345520,2153658,15699190,8098035,2152900,9063881,28189581

6D6718AC72C9D86EDE16B191EDAB3ABA488B689B

Page visits: 1690

Time of last update: 2021-09-09 19:55:12

Author of last update: Melvin.boenninger