trxA
168
thioredoxin, antioxidative action by facilitating the reduction of other proteins by cysteine thiol-disulfide exchange, important for the prevention of protein aggregation during severe heat stress, cleavage of CoA moieties from modified proteins
locus
BSU_28500
Molecular weight
11.25 kDa
pI
4.31
function
protection of proteins against oxidative damage
product
thioredoxin
essential
yes
synonyms
trxA, trx
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG3118 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,913,024 2,913,338
Phenotypes of a mutant
essential [Pubmed|12682299]
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The protein
Catalyzed reaction/ biological activity
cleavage of CoA moieties from modified proteins [pubmed|37107313]
Protein family
[wiki|Thioredoxin family] (according to UniProt)
[wiki|Domains]
Thioredoxin domain (aa 2-104) (according to UniProt)
Structure
[PDB|2GZZ] (oxidized form), [PDB|2GZY] (reduced form), [PDB|2IPA] (TrxA-ArsC-complex) [Pubmed|17303556]
[AF|P14949]
Paralogous protein(s)
[protein|A245594D3F37ACE6B99855DDDFEC27F7F21579E4|ydbP], [protein|4A8B6D88FEA9D18E1BAE08847A5F7683F9D6CDF4|yosR]
[wiki|Localization]
cytoplasm [Pubmed|17501922]
Expression and Regulation
Operons
genes
[gene|4E5C84FDC8FE2FEFF47306C91ECAB7F17D3E38E9|trxA]
description
[Pubmed|9537387]
regulation
induced by heat stress ([protein|908DB17A39D518E84977250C55825E77FA02E391|ctsR]) [Pubmed|9852015]
regulatory mechanism
[protein|908DB17A39D518E84977250C55825E77FA02E391|ctsR]: repression, [Pubmed|9852015], in [regulon|protein:908DB17A39D518E84977250C55825E77FA02E391|ctsR regulon]
[protein|2C6386E9A63F410558D168798D077DF91590F454|spx]: activation, [pubmed|29271514], in [regulon|protein:2C6386E9A63F410558D168798D077DF91590F454|spx regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|9537387], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [Pubmed|9537387,11544224], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]
additional information
induced by cell wall stress ([protein|2C6386E9A63F410558D168798D077DF91590F454|spx]) [pubmed|29271514]
A [protein|search|ncRNA] is predicted between [protein|4E5C84FDC8FE2FEFF47306C91ECAB7F17D3E38E9|trxA] and [protein|1DF08A474E95909EAF68CF26D97DD49350ABEA89|abf2] [PubMed|20525796]
References
Reviews
Original Publications
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Time of last update: 2024-04-16 08:02:01
Author of last update: Jstuelk