sfp/1
168
4-phosphopantetheinyl transferase (surfactin synthetase-activating enzyme), required for production of surfactin, plipastatin and bacillaene, inactive pseudogene in strain 168
locus
BSU_03569
function
phosphopantetheinylates a serine residue in each of the seven peptidyl carrier protein domains of the first three subunits of surfactin synthetase (SrfAA-SrfAB-SrfAC) and AcpK
product
4-phosphopantetheinyl transferase
essential
no
ec
null
synonyms
sfp/1, sfp
Outlinks
Genomic Context
Categories containing this gene/protein
This gene is a member of the following regulons
Gene
Coordinates
407,460 407,627
Phenotypes of a mutant
No swarming motility on B medium. [Pubmed|19202088]
The protein
Catalyzed reaction/ biological activity
CoA + apo-[peptidyl-carrier protein] = adenosine 3',5'-bisphosphate + holo-[peptidyl-carrier protein] (according to Swiss-Prot)
Protein family
Gsp/sfp/hetI/acpT family (according to Swiss-Prot)
Biological materials
Mutant
BKE03569 ([gene|1C4F076D54F5A07AC351D722A403F249ED097555|sfp/1]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE03569 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CTGGTGCAGGCGCACTGAAA, downstream forward: _UP4_ACAATGGTCTCGTACGAAGA
BKK03569 ([gene|1C4F076D54F5A07AC351D722A403F249ED097555|sfp/1]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK03569 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CTGGTGCAGGCGCACTGAAA, downstream forward: _UP4_ACAATGGTCTCGTACGAAGA
labs
[wiki|Mohamed Marahiel], Marburg University, Germany [http://www.uni-marburg.de/fb15/fachgebiete/bio/marahiel?language_sync=1 homepage]
References
Reviews
Original Publications
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Time of last update: 2025-03-13 15:35:30
Author of last update: Jstuelk