Mon Aug 31 2015 13:56:21 GMT+0200 (CEST)2025-05-24 03:15:02
locus
BSU30210
BSU_30210
outlinks
bsu
BSU30210
BSU_30210
syns
[SW|Categories] containing this gene/protein
[SW|biosynthesis of cofactors]
The protein
Catalyzed reaction/ biological activity
ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin (according to Swiss-Prot)
7,8-diaminononanoate + ATP + CO2 = ADP + dethiobiotin + 3 H+ + phosphate (according to UniProt)
The protein
Protein family
dethiobiotin synthetase family (according to Swiss-Prot)
dethiobiotin synthetase family (single member, according to UniProt)
Expression and Regulation
Operon
''[[protein|bioW]]-[[protein|bioA]]-[[protein|bioF]]-[[protein|bioD]]-[[protein|bioB]]-[[protein|bioI]]-[[protein|ytbQ]]'' [Pubmed|8763940,8892842]
Expression and Regulation
Regulation
repressed in the presence of biotin ([[protein|BirA]]) [Pubmed|8763940,8892842]
Expression and Regulation
Regulatory mechanism
[[protein|BirA]]: transcription repression [Pubmed|8763940,8892842]
References
Reviews
[Pubmed|21437340]==
Original publications
proteinLength
231
geneLength
696
Gene
Coordinates
3,091,492 → 3,092,187
The protein
Paralogous protein(s)
[[this]]
The protein
Structure
[PDB|1DTS] (from E. coli, 32% identity) [pubmed|8081756]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
BKE30210 (Δ[[gene|bioD]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE30210 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AGTTCCCGTCACAAAAAAAC, downstream forward: _UP4_ATGAATCAAGTGGGGGTATG
BKK30210 (Δ[[gene|bioD]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK30210 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AGTTCCCGTCACAAAAAAAC, downstream forward: _UP4_ATGAATCAAGTGGGGGTATG
References
Original publications