S-ribosylhomocysteine lyase, autoinducer-2 production protein, required for surface spreading motility (sliding) of B. subtilis natto and biofilm formation
function
methionine salvage
product
S-ribosylhomocysteine lyase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.10|Biosynthesis/ acquisition of methionine/ S-adenosylmethionine][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.8|Quorum sensing][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.1|Motility and chemotaxis] → [category|SW 4.1.1.1|Signal transduction in motility and chemotaxis] → [category|SW 4.1.1.1.5|Additional chemotaxis signal transduction and regulatory proteins][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation] → [category|SW 4.1.2.5|Other proteins required for biofilm formation][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids], [SW|motility and chemotaxis], [SW|quorum sensing], [SW|biofilm formation]Gene
Coordinates on the chromosome (coding sequence)
3,137,495 -> 3,137,968
The protein
Catalyzed reaction/ biological activity
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine (4S)-4,5-dihydroxypentan-2,3-dione (according to Swiss-Prot) Protein family
luxS family (according to Swiss-Prot)Effectors of protein activity
subject to feedback inhibition [Pubmed|19258532]Structure
[PDB|1JQW] (complex with homocysteine), [PDB|1J98] [Pubmed|11601850]Expression and Regulation
Operon
''luxS'' [Pubmed|9387221]Additional information
subject to feedback inhibition [http://www.ncbi.nlm.nih.gov/sites/entrez/19258532 PubMed]Biological materials
Mutant
1A953 ( ''luxS''::''cat''), [Pubmed|17056751], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A953&Search=1A953 BGSC]References
11553770,19258532,9387221,16740951,26779171,17056751,11601850 
