transcriptional regulator, controls manganese import and efflux
function
regulation of manganese transport
product
transcriptional regulator (DtxR family)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.2|Trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)] → [category|SW 1.3.2.2|Manganese][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other][SW|Categories] containing this gene/protein
[SW|trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)], [SW|transcription factors and their control], [SW|membrane proteins], [SW|sporulation/ other]Gene
Coordinates on the chromosome (coding sequence)
2,543,440 -> 2,543,868
Phenotypes of a mutant
inactivation of ''[SW|mntR]'' reduces sporulation efficiency to 8.9% that of wild type cells [Pubmed|26735940]highly sensitive to Mn(II) intoxication [Pubmed|27748968]The protein
[SW|Cofactors]
Mn(2) acts as co-repressor (according to [Pubmed|20408793]) Structure
[PDB|2F5D] (complex with manganese), [PDB|2HYG] (apo-form)[SW|Localization]
cell membrane (according to Swiss-Prot)[SW|Interactions]
active as dimer (according to [Pubmed|20408793])Labs working on this gene/protein
[SW|John Helmann], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage][SW|Richard Brennan], Houston, Texas, USA [http://www.mdanderson.org/departments/biochem/display.cfm?id=556ef368-6c81-4043-b74f350d41dd06cb&method=displayfull&pn=a8427ebd-d0ff-11d4-80fd00508b603a14 Homepage]References
Reviews
Original Publications
17176058,12675807,17118401,16533030,15736948,14580210,12847518,23298157,12950915,10760146,26735940,27748968 
