SAVE THE DATE!
21st International Conference on Bacilli and Gram-Positive Bacteria. Prague, Czech Republic, June 7-11, 2021.
categories[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 22.214.171.124|Aminoacyl-tRNA synthetases][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
3,102,629 → 3,105,043
Phenotypes of a mutantessential [Pubmed|12682299]
Catalyzed reaction/ biological activityATP + L-leucine + tRNALeu --> AMP + diphosphate + L-leucyl-tRNALeu (according to UniProt)
Protein family[SW|Class-I aminoacyl-tRNA synthetase family] (according to UniProt)
Structure[PDB|2AJG] (from ''Escherichia coli'', 39% identity, 56% similarity) [Pubmed|16277600]
[SW|Localization]cytoplasm (according to Swiss-Prot)
Expression and Regulation
regulatory mechanism[regulon|T-box|T-box]: transcription antitermination, via uncharged tRNA-Leu binding to [SW|RNA switch], in [regulon|T-box|T-box]
regulationinduced by leucine limitation ([protein|search|T-box]) [Pubmed|1317842]view in new tab