SubtiBank SubtiBank
spoVC
An ordered knock out library of all non-essential genes in B. subtilis is now available at Addgene. Information on ordering a copy can be found here. See Koo et al. 2017 for details about library construction.

spoVC

general stress protein, peptidyl-tRNA hydrolase
locus
BSU00530
pI
5.58
mw
20.73 kDa
protein length
188 aa Sequence Blast
gene length
564 bp Sequence Blast
function
spore coat formation
product
peptidyl-tRNA hydrolase
essential
yes
ec
3.1.1.29
synonyms
pth

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.12|Translation/ other]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • Gene

    Coordinates
    59,504 → 60,070

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • N-substituted aminoacyl-tRNA H2O = N-substituted amino acid tRNA (according to Swiss-Prot)
  • Protein family

  • PTH family (according to Swiss-Prot)
  • Structure

  • [PDB|4QT4] (from ''Streptococcus pyogenes'', 48% identity) [Pubmed|25389518]
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • Expression and Regulation

    Operons

    genes
    [gene|40624E9FC30D75D172EF098C7FAC77B2573CC129|ctc]-[gene|FE7859E98F26E532AE02CD71B42B845BADBCF06E|spoVC]-[gene|C595D32D98723E93AF26B5C864FD61AF4739E069|fin]
    description
    [pubmed|22383849]

    sigma factors

  • [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB]: sigma factor, [pubmed|15805528], in [regulon|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB regulon]
  • regulation

  • induced under stress conditions ([protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB]) [pubmed|15805528]
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    References

  • 11544224,12100553,25389518